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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Leptin, Estrogens and Cancer

Author(s): Maria del Carmen Maeso Fortuny, Buenaventura Brito Diaz and Antonio Cabrera de Leon

Volume 6, Issue 8, 2006

Page: [897 - 907] Pages: 11

DOI: 10.2174/138955706777934973

Price: $65

Abstract

Obesity is a state of leptin resistance in which the membrane leptin receptor and the JAK-STAT pathway are blocked. This leads to increased intracellular concentrations of lipid metabolites, increased non-oxidative metabolism by adipocytes, and stimulation of the cell estrogen cycle. These factors are potentially oncogenic via the shared mitogen-activated protein kinase (MAPK), mitogen/extracellular signal-regulated kinase (MEK) and extracellular signal-regulated kinase (ERK) cellular pathways.

Keywords: Cancer, leptin, estrogen receptors


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