Abstract
For decades, neurologic and pulmonary disorders have been associated to diabetes mellitus (DM) and more recently to obesity. Many studies have attempted to establish the association between sleep apnea and adult-onset DM. Growing evidence exists demonstrating the association between insulin-resistance and obstructive sleep apnea (OSA), as well as sleep-disordered breathing (SDB) in non-obese diabetic patients with autonomic neuropathy. In patients with DM, two types of sleep disorders can be found; upper airway resistance syndrome and sleep apnea. The later apnea can be central, obstructive or mixed. In either case, a decrease in the oxygen saturation will ensue, and sleep arousal will occur. The diagnosis of sleep apnea in patients with DM is mainly done by obtaining a good history and physical examination. The main symptoms in the patient with sleep apnea include excessive daytime sleepiness (frequently seen in situations which are not mentally demanding). Effective continued positive airway pressure (CPAP) treatment show clinical improvement in symptoms as well as in insulin sensitivity. The relation between SDB and DM can have significant impact on the overall health of the patient.
Keywords: Sleep apnea, sleep-related disorders, insulin resistance, diabetes mellitus, obesity
Current Respiratory Medicine Reviews
Title: Sleep-Related Disorders, Diabetes and Obesity: Understanding the Facts
Volume: 2 Issue: 3
Author(s): Javier Nieto, Salim Surani, Ana L. Huerta-Alardin and Joseph Varon
Affiliation:
Keywords: Sleep apnea, sleep-related disorders, insulin resistance, diabetes mellitus, obesity
Abstract: For decades, neurologic and pulmonary disorders have been associated to diabetes mellitus (DM) and more recently to obesity. Many studies have attempted to establish the association between sleep apnea and adult-onset DM. Growing evidence exists demonstrating the association between insulin-resistance and obstructive sleep apnea (OSA), as well as sleep-disordered breathing (SDB) in non-obese diabetic patients with autonomic neuropathy. In patients with DM, two types of sleep disorders can be found; upper airway resistance syndrome and sleep apnea. The later apnea can be central, obstructive or mixed. In either case, a decrease in the oxygen saturation will ensue, and sleep arousal will occur. The diagnosis of sleep apnea in patients with DM is mainly done by obtaining a good history and physical examination. The main symptoms in the patient with sleep apnea include excessive daytime sleepiness (frequently seen in situations which are not mentally demanding). Effective continued positive airway pressure (CPAP) treatment show clinical improvement in symptoms as well as in insulin sensitivity. The relation between SDB and DM can have significant impact on the overall health of the patient.
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Cite this article as:
Nieto Javier, Surani Salim, Huerta-Alardin L. Ana and Varon Joseph, Sleep-Related Disorders, Diabetes and Obesity: Understanding the Facts, Current Respiratory Medicine Reviews 2006; 2 (3) . https://dx.doi.org/10.2174/157339806778019006
DOI https://dx.doi.org/10.2174/157339806778019006 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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