Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids

Title: Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids

Volume: 3 Issue: 6

Author(s): Vladimira Moulisova, Jiri Sebestian, Olga Jedlickova, Alexandr Jegorov and Stepanka B. Sebestianova

Affiliation:

Keywords: Cyclosporin A, silymarin flavonoids, hepatocytes, membrane transport

Abstract: Interactions between cyclosporin A and three silymarin flavonoids (silybin, silydianin, and silychristin) were studied on the rat hepatocyte plasma membrane using the replacement of [3H]cyclosporin A by silymarin flavonoids. It was found that flavonoids significantly replaced CsA from its binding to the rat hepatocyte plasma membrane. It seems that these two types of compounds are competitors at the same binding site of the plasma membrane receptor.

Cite this article as:

Moulisova Vladimira, Sebestian Jiri, Jedlickova Olga, Jegorov Alexandr and Sebestianova B. Stepanka, Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids, Letters in Drug Design & Discovery 2006; 3 (6) . https://dx.doi.org/10.2174/157018006777805567