Abstract
Structural-energetic analysis of peptide and protein antigens in the context of binding to antibody reveals fundamental differences between the cross-reactions of antipeptide antibody with protein and antiprotein antibody with peptide, providing a physicochemical basis for B-cell epitope prediction as applied to the development of peptide-based vaccines and immunodiagnostics.
Keywords: B-cell epitope prediction, antipeptide antibody, antiprotein antibody, peptide-protein cross-reactivity, structural energetics, solvent-accessible surface area
Protein & Peptide Letters
Title: A Structural-Energetic Basis for B-Cell Epitope Prediction
Volume: 13 Issue: 7
Author(s): Salvador Eugenio C. Caoili
Affiliation:
Keywords: B-cell epitope prediction, antipeptide antibody, antiprotein antibody, peptide-protein cross-reactivity, structural energetics, solvent-accessible surface area
Abstract: Structural-energetic analysis of peptide and protein antigens in the context of binding to antibody reveals fundamental differences between the cross-reactions of antipeptide antibody with protein and antiprotein antibody with peptide, providing a physicochemical basis for B-cell epitope prediction as applied to the development of peptide-based vaccines and immunodiagnostics.
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Cite this article as:
Caoili C. Salvador Eugenio, A Structural-Energetic Basis for B-Cell Epitope Prediction, Protein & Peptide Letters 2006; 13 (7) . https://dx.doi.org/10.2174/092986606777790502
DOI https://dx.doi.org/10.2174/092986606777790502 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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