Abstract
In the last years scientific interest in homocysteine is growing. Homocysteine is a risk factor for cardiovascular morbidity and mortality in the general population with normal renal function. The relationship between homocysteine and cardiovascular disease in patients with renal failure is unclear. This review shows up homocysteine metabolism and its interactions with drugs and diseases, summarizes homocysteines toxic effects and the results of clinical studies about the effects of homocysteine-lowering therapy on hard endpoints like cardiovascular morbidity and mortality, and describes which kind of treatment can reduce homocysteine in dialysis patients.
Keywords: Homocysteine, folic acid, vitamin B, cardiovascular disease
Letters in Drug Design & Discovery
Title: Homocysteine and Folate Therapy in Dialysis Patients
Volume: 3 Issue: 5
Author(s): Marco Righetti
Affiliation:
Keywords: Homocysteine, folic acid, vitamin B, cardiovascular disease
Abstract: In the last years scientific interest in homocysteine is growing. Homocysteine is a risk factor for cardiovascular morbidity and mortality in the general population with normal renal function. The relationship between homocysteine and cardiovascular disease in patients with renal failure is unclear. This review shows up homocysteine metabolism and its interactions with drugs and diseases, summarizes homocysteines toxic effects and the results of clinical studies about the effects of homocysteine-lowering therapy on hard endpoints like cardiovascular morbidity and mortality, and describes which kind of treatment can reduce homocysteine in dialysis patients.
Export Options
About this article
Cite this article as:
Righetti Marco, Homocysteine and Folate Therapy in Dialysis Patients, Letters in Drug Design & Discovery 2006; 3 (5) . https://dx.doi.org/10.2174/157018006777574140
DOI https://dx.doi.org/10.2174/157018006777574140 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Association of Genetic Polymorphisms of CYP2C9 and VKORC1 with Bleeding Following Warfarin: A Case-Control Study
Current Clinical Pharmacology Astrocytic Target Mechanisms in Epilepsy
Current Medicinal Chemistry The Evolution of Schizophrenia: A Model for Selection by Infection, with a Focus on NAD
Current Pharmaceutical Design Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
Current Drug Safety Approaching Neurological Diseases to Reduce Mobility Limitations in Older Persons
Current Pharmaceutical Design Non-adenosine Nucleoside Inosine, Guanosine and Uridine as Promising Antiepileptic Drugs: a Summary of Current Literature
Mini-Reviews in Medicinal Chemistry Phosphodiesterase 7A: A New Therapeutic Target for Alleviating Chronic Inflammation?
Current Pharmaceutical Design C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside
Current Neuropharmacology New Glycoside Esters from the Aerial Parts of Artemisia absinthium Linn.
The Natural Products Journal Synthesis and First Evaluation of [<sup>18</sup>F]Fluorocyano- and [<sup>18</sup>F]Fluoronitroquinoxalinedione as Putative AMPA Receptor Antagonists
Medicinal Chemistry Intraoperative Seizures: Anesthetic and Antiepileptic Drugs
Current Pharmaceutical Design Regulatory Triangle of Neurodegeneration, Adult Neurogenesis and MicroRNAs
CNS & Neurological Disorders - Drug Targets Microtubules (tau) as an Emerging Therapeutic Target: NAP (Davunetide)
Current Pharmaceutical Design Alkaloids as Important Scaffolds in Therapeutic Drugs for the Treatments of Cancer, Tuberculosis, and Smoking Cessation
Current Topics in Medicinal Chemistry Valeriana jatamansi Constituent IVHD-valtrate As a Novel Therapeutic Agent to Human Ovarian Cancer: in vitro and in vivo Activities and Mechanisms
Current Cancer Drug Targets Stem Cell Behavior at Hypothermia: A Review Article
Current Stem Cell Research & Therapy Dysfunctions of the Diffusional Membrane Pathways Mediated Hemichannels in Inherited and Acquired Human Diseases
Current Vascular Pharmacology Cognitive Identity in Schizophrenia: Vision, Space, and Body Perception from Prodrome to Syndrome
Current Psychiatry Reviews Tools in the Design of Therapeutic Drugs for CNS Disorders: An up-to-date Review
Current Molecular Pharmacology Syntheses, Transformations and Pharmaceutical Applications of Kynurenic Acid Derivatives
Current Medicinal Chemistry