Deciphering Signaling Control by Phosphoproteome Using Mass Spectrometry

Title: Deciphering Signaling Control by Phosphoproteome Using Mass Spectrometry

Volume: 13 Issue: 5

Author(s): Yuet-Kin Leung and John W. Ho

Affiliation:

Keywords: Mass spectrometry, proteome, genes, signaling molecules

Abstract: Analysis of changes in genes and protein profiles provides invaluable information to understand the activities and functions of proteins. However, their activities are further regulated by post-translational modifications, such as glycosylation and phosphorylation. Cell growth and apoptotic pathways are good examples of demonstrating the roles of phosphorylation in activation of protein cascades upon stimulation.

Cite this article as:

Leung Yuet-Kin and Ho W. John, Deciphering Signaling Control by Phosphoproteome Using Mass Spectrometry, Protein & Peptide Letters 2006; 13 (5) . https://dx.doi.org/10.2174/092986606776819664