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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Opioid Receptor-Like (ORL1) Receptor Utilizes Both GoA and GoB for Signal Transductio

Author(s): Prudence H. Tso and Yung H. Wong

Volume 13, Issue 5, 2006

Page: [437 - 441] Pages: 5

DOI: 10.2174/092986606776819547

Price: $65

Abstract

The ORL1 receptors stably expressed in HEK 293 cells can utilize PTX-resistant mutants of GαoA/B to inhibit adenylyl cyclase (AC) and stimulate extracellular signal-regulated protein kinases (ERKs). However, development of AC superactivation and loss of ERK1/2 responsiveness induced by chronic activation of the ORL1 receptors remained PTXsensitive.

Keywords: Adenylyl cyclase, ERK, G proteins, ORL1 receptor, signal transduction, superactivation


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