Abstract
The ORL1 receptors stably expressed in HEK 293 cells can utilize PTX-resistant mutants of GαoA/B to inhibit adenylyl cyclase (AC) and stimulate extracellular signal-regulated protein kinases (ERKs). However, development of AC superactivation and loss of ERK1/2 responsiveness induced by chronic activation of the ORL1 receptors remained PTXsensitive.
Keywords: Adenylyl cyclase, ERK, G proteins, ORL1 receptor, signal transduction, superactivation
Protein & Peptide Letters
Title: Opioid Receptor-Like (ORL1) Receptor Utilizes Both GoA and GoB for Signal Transductio
Volume: 13 Issue: 5
Author(s): Prudence H. Tso and Yung H. Wong
Affiliation:
Keywords: Adenylyl cyclase, ERK, G proteins, ORL1 receptor, signal transduction, superactivation
Abstract: The ORL1 receptors stably expressed in HEK 293 cells can utilize PTX-resistant mutants of GαoA/B to inhibit adenylyl cyclase (AC) and stimulate extracellular signal-regulated protein kinases (ERKs). However, development of AC superactivation and loss of ERK1/2 responsiveness induced by chronic activation of the ORL1 receptors remained PTXsensitive.
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Cite this article as:
Tso H. Prudence and Wong H. Yung, Opioid Receptor-Like (ORL1) Receptor Utilizes Both GoA and GoB for Signal Transductio, Protein & Peptide Letters 2006; 13 (5) . https://dx.doi.org/10.2174/092986606776819547
DOI https://dx.doi.org/10.2174/092986606776819547 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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