Abstract
Considerable information on the functions of prion protein (PrP) has been accumulated. One experimental approach is the use of PrP gene-knockout mice and derived cell lines. This approach has contributed to elucidating the functions of cellular prion protein (PrPC), such as its anti-oxidative and anti-apoptotic roles. This review will introduce the recent advances in prion biology made possible by the availability of these tools.
Keywords: Prion protein, PrP-knockout mice, PrP-deficient cells, apoptosis, oxidative stress
Mini-Reviews in Medicinal Chemistry
Title: Recent Advances in Clarifying Prion Protein Functions Using Knockout Mice and Derived Cell Lines
Volume: 6 Issue: 5
Author(s): Akikazu Sakudo, Takashi Onodera, Yoshikazu Suganuma, Takanori Kobayashi, Keiichi Saeki and Kazuyoshi Ikuta
Affiliation:
Keywords: Prion protein, PrP-knockout mice, PrP-deficient cells, apoptosis, oxidative stress
Abstract: Considerable information on the functions of prion protein (PrP) has been accumulated. One experimental approach is the use of PrP gene-knockout mice and derived cell lines. This approach has contributed to elucidating the functions of cellular prion protein (PrPC), such as its anti-oxidative and anti-apoptotic roles. This review will introduce the recent advances in prion biology made possible by the availability of these tools.
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Cite this article as:
Sakudo Akikazu, Onodera Takashi, Suganuma Yoshikazu, Kobayashi Takanori, Saeki Keiichi and Ikuta Kazuyoshi, Recent Advances in Clarifying Prion Protein Functions Using Knockout Mice and Derived Cell Lines, Mini-Reviews in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/138955706776876159
DOI https://dx.doi.org/10.2174/138955706776876159 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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