Abstract
Inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase (statins) are widely used for the prevention of atherosclerotic diseases. The effects of statins on the generation of reactive oxygen species (ROS) by in vitro and in vivo were studied. Administration of statins significantly decreased ROS generation in vitro and in vivo.
Keywords: Statins, oxidative stress, atherosclerosis, carotid artery, leukocytes, flow cytemetory
Mini-Reviews in Medicinal Chemistry
Title: Antioxidative Actions of Statins: Potential Mechanisms for Antiathersclerotic Effects
Volume: 6 Issue: 5
Author(s): Takanori Watanabe, Kenichi Yasunari and Munehoro Nakamura
Affiliation:
Keywords: Statins, oxidative stress, atherosclerosis, carotid artery, leukocytes, flow cytemetory
Abstract: Inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase (statins) are widely used for the prevention of atherosclerotic diseases. The effects of statins on the generation of reactive oxygen species (ROS) by in vitro and in vivo were studied. Administration of statins significantly decreased ROS generation in vitro and in vivo.
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Cite this article as:
Watanabe Takanori, Yasunari Kenichi and Nakamura Munehoro, Antioxidative Actions of Statins: Potential Mechanisms for Antiathersclerotic Effects, Mini-Reviews in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/138955706776876249
DOI https://dx.doi.org/10.2174/138955706776876249 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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