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Mini-Reviews in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Fluorine Containing Molecules for Peptidomimicry: A Chemical Act to Modulate Enzymatic Activity

Author(s): C. E. Oyiliagu, M. Novalen and L. P. Kotra

Volume 3, Issue 2, 2006

Page: [99 - 115] Pages: 17

DOI: 10.2174/157019306776819235

Price: $65

Abstract

Fluorine atom has been used extensively to modulate the properties of various peptide-like compounds to modulate enzyme activities such as proteases. Fluorinated functionalities such as trifluoromethyl group, difluoromethyl group, fluoromethyl moiety and recently -CHF-S- were investigated. This article discusses important fluorine containing peptidomimetics, synthetic strategies, and the modulation of enzymic activities.

Keywords: Fluoropeptidomimetics, fluorine substitution, peptidomimicry, protease inhibitors


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