Abstract
Fluorine atom has been used extensively to modulate the properties of various peptide-like compounds to modulate enzyme activities such as proteases. Fluorinated functionalities such as trifluoromethyl group, difluoromethyl group, fluoromethyl moiety and recently -CHF-S- were investigated. This article discusses important fluorine containing peptidomimetics, synthetic strategies, and the modulation of enzymic activities.
Keywords: Fluoropeptidomimetics, fluorine substitution, peptidomimicry, protease inhibitors
Mini-Reviews in Organic Chemistry
Title: Fluorine Containing Molecules for Peptidomimicry: A Chemical Act to Modulate Enzymatic Activity
Volume: 3 Issue: 2
Author(s): C. E. Oyiliagu, M. Novalen and L. P. Kotra
Affiliation:
Keywords: Fluoropeptidomimetics, fluorine substitution, peptidomimicry, protease inhibitors
Abstract: Fluorine atom has been used extensively to modulate the properties of various peptide-like compounds to modulate enzyme activities such as proteases. Fluorinated functionalities such as trifluoromethyl group, difluoromethyl group, fluoromethyl moiety and recently -CHF-S- were investigated. This article discusses important fluorine containing peptidomimetics, synthetic strategies, and the modulation of enzymic activities.
Export Options
About this article
Cite this article as:
Oyiliagu E. C., Novalen M. and Kotra P. L., Fluorine Containing Molecules for Peptidomimicry: A Chemical Act to Modulate Enzymatic Activity, Mini-Reviews in Organic Chemistry 2006; 3 (2) . https://dx.doi.org/10.2174/157019306776819235
DOI https://dx.doi.org/10.2174/157019306776819235 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Molecular Effects of L-dopa Therapy in Parkinson’s Disease
Current Genomics Cardiovascular Morbidity and Mortality in Obstructive Sleep Apnea
Current Pharmaceutical Design Anti-Endothelial Cell Antibodies in Patients with Cerebral Small Vessel Disease
Current Neurovascular Research Prostacyclin, Atherothrombosis, and Cardiovascular Disease
Current Medicinal Chemistry Similarities Between Pre-Eclampsia and Atherosclerosis: A Protective Effect of Physical Exercise?
Current Medicinal Chemistry Acknowledgements to Reviewers
Current Hypertension Reviews Nucleolar Localization Signals of LIM Kinase 2 Function as a Cell- Penetrating Peptide
Protein & Peptide Letters Myths and Facts Concerning the Use of Statins in Very Old Patients
Cardiovascular & Hematological Disorders-Drug Targets Migration and Function of Th17 Cells
Inflammation & Allergy - Drug Targets (Discontinued) Neuronal Response of Peroxisomal and Peroxisome-Related Proteins to Chronic and Acute Aβ Injury
Current Alzheimer Research Modern Alchemy with Metal Complexes Inside Cyclodextrins, The Molecular Cauldrons
Current Organic Chemistry Thiazolidinediones and Cardiovascular Risk — A Question of Balance
Current Cardiology Reviews Gene Therapy and Cell Reprogramming For the Aging Brain: Achievements and Promise
Current Gene Therapy Pharmacological Chemistry and Biomedical Implications of Chemical Ingredients from <i>Parthenium hysterophorus</i>
Current Topics in Medicinal Chemistry Emerging Therapy Options in Heparin-Induced Thrombocytopenia
Cardiovascular & Hematological Agents in Medicinal Chemistry Present Situation of the Development of Cellular-Type Hemoglobin-Based Oxygen Carrier (Hemoglobin-Vesicles)
Current Drug Discovery Technologies Serum Uric Acid and Progression of Autosomal Dominant Polycystic Kidney Disease: Results from the HALT PKD Trials
Current Hypertension Reviews Alzheimer’s Disease and Antioxidant Therapy: How Long How Far?
Current Medicinal Chemistry Does Metabolic Syndrome or its Individual Components Affect Pain and Function in Knee Osteoarthritis Women?
Current Rheumatology Reviews Non-viral Gene Delivery and Therapeutics Targeting to Brain
Current Nanoscience