Leukocyte Function-Associated Antigen-1: Structure, Function and Application Prospects

Title: Leukocyte Function-Associated Antigen-1: Structure, Function and Application Prospects

Volume: 13 Issue: 4

Author(s): Ma Xingyuan, Zheng Wenyun and Wang Tianwen

Affiliation:

Keywords: LFA-1, structure, function, pathological role, drug designing

Abstract: This review focuses on the structure, function and pathological role of leukocyte function-associated antigen-1 (LFA-1) which is a heterodimeric protein consisting of two subunits. LFA-1 plays a most important role in the immune system including adhesion, extravasation, migration, apoptosis, cytotoxicity, cytokine production, and proliferation of lymphocytes. Therefore, T-cell activation can be suppressed by blocking ICAM-1/LFA-1 interaction in autoimmune diseases and organ transplantation. Many different inhibitors (i.e. antibodies, peptides, small molecules) have been demonstrated to block ICAM-1/LFA-1 interaction, and some of them are promising for medical treatment or have reached clinical trials.

Cite this article as:

Xingyuan Ma, Wenyun Zheng and Tianwen Wang, Leukocyte Function-Associated Antigen-1: Structure, Function and Application Prospects, Protein & Peptide Letters 2006; 13 (4) . https://dx.doi.org/10.2174/092986606775974429