Cyclization of α-Synuclein Derived Peptide Increases Its Chaperone-Like Activity

Title: Cyclization of α-Synuclein Derived Peptide Increases Its Chaperone-Like Activity

Volume: 13 Issue: 4

Author(s): Thomas D. Kim

Affiliation:

Keywords: α-Synuclein, chaperone-like activity, protective molecule, aggregation

Abstract: We have analyzed a series of peptides derived from the C-terminus of α-synuclein for chaperone-like activity. Specifically, a cyclic peptide generated by introducing a disulfide bond was observed to increase chaperone-like activity. This is the first example of a disulfide-crosslinked peptide that exhibits activity against protein aggregation and activity loss.

Cite this article as:

Kim D. Thomas, Cyclization of α-Synuclein Derived Peptide Increases Its Chaperone-Like Activity, Protein & Peptide Letters 2006; 13 (4) . https://dx.doi.org/10.2174/092986606775974438