Abstract
In asthma, inflammatory and structural cells contribute to increased bronchoconstriction acutely and more chronically to airway remodelling. Current asthma therapy doesnt inhibit these features satisfactorily. This review discusses Rho-kinase as a potential drug target, since increasing evidence suggests a central role for this pathway in acute and chronic airway hyperresponsiveness.
Keywords: Airway remodelling, airway smooth muscle, airway inflammation, Y-27632, fasudil
Mini-Reviews in Medicinal Chemistry
Title: Rho-Kinase as a Drug Target for the Treatment of Airway Hyperresponsiveness in Asthma
Volume: 6 Issue: 3
Author(s): Reinoud Gosens, Dedmer Schaafsma, S. A. Nelemans and Andrew J. Halayko
Affiliation:
Keywords: Airway remodelling, airway smooth muscle, airway inflammation, Y-27632, fasudil
Abstract: In asthma, inflammatory and structural cells contribute to increased bronchoconstriction acutely and more chronically to airway remodelling. Current asthma therapy doesnt inhibit these features satisfactorily. This review discusses Rho-kinase as a potential drug target, since increasing evidence suggests a central role for this pathway in acute and chronic airway hyperresponsiveness.
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Cite this article as:
Gosens Reinoud, Schaafsma Dedmer, Nelemans A. S. and Halayko J. Andrew, Rho-Kinase as a Drug Target for the Treatment of Airway Hyperresponsiveness in Asthma, Mini-Reviews in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/138955706776073402
DOI https://dx.doi.org/10.2174/138955706776073402 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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