Abstract
In the past two decades a large initiative has been put forth to understand the biological and pathogenic properties of the human T-cell lymphotropic virus type 1 (HTLV-1); this has ultimately led to the development of various experimental vaccination and therapeutic strategies to combat HTLV-1 infection. The focus of this work is to outline key targets for the design of therapeutics for HTLV-1, such as fusion mediated by the envelope glycoprotein, and to discuss reports of novel vaccines or therapeutics. These strategies include peptide, recombinant protein, DNA, and viral vectors. The final focus of this review is to acquaint the reader with vaccine approaches developed in our laboratory over the last decade. These strategies include the development of envelope glycoprotein derived B-cell epitopes for the induction of neutralizing antibodies, as well as a strategy to generate a multivalent cytotoxic T-lymphocyte (CTL) response against the HTLV-1 Tax antigen.
Keywords: central nervous system, envelope glycoprotein (Env), epitopes, Cytotoxic T-cells, Immunization, Tetanus toxoid
Current Protein & Peptide Science
Title: Advances in HTLV-1 Peptide Vaccines and Therapeutics
Volume: 7 Issue: 2
Author(s): Marcus P. Lynch and Pravin T.P. Kaumaya
Affiliation:
Keywords: central nervous system, envelope glycoprotein (Env), epitopes, Cytotoxic T-cells, Immunization, Tetanus toxoid
Abstract: In the past two decades a large initiative has been put forth to understand the biological and pathogenic properties of the human T-cell lymphotropic virus type 1 (HTLV-1); this has ultimately led to the development of various experimental vaccination and therapeutic strategies to combat HTLV-1 infection. The focus of this work is to outline key targets for the design of therapeutics for HTLV-1, such as fusion mediated by the envelope glycoprotein, and to discuss reports of novel vaccines or therapeutics. These strategies include peptide, recombinant protein, DNA, and viral vectors. The final focus of this review is to acquaint the reader with vaccine approaches developed in our laboratory over the last decade. These strategies include the development of envelope glycoprotein derived B-cell epitopes for the induction of neutralizing antibodies, as well as a strategy to generate a multivalent cytotoxic T-lymphocyte (CTL) response against the HTLV-1 Tax antigen.
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Cite this article as:
Lynch P. Marcus and Kaumaya T.P. Pravin, Advances in HTLV-1 Peptide Vaccines and Therapeutics, Current Protein & Peptide Science 2006; 7 (2) . https://dx.doi.org/10.2174/138920306776359803
DOI https://dx.doi.org/10.2174/138920306776359803 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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