Abstract
Wolbachia endosymbionts of filariae are targets for the development of new antifilarial chemotherapy. Doxycycline to deplete Wolbachia from the worm has demonstrated the feasibility of this strategy and has provided a new chemotherapeutic tool. Recent research shows that depleting Wolbachia will also lessen pathology, and lessen adverse reactions to traditional antifilarial drugs.
Keywords: Lymphatic filariasis, onchocerciasis, Wolbachia, tetracycline, doxycycline
Mini-Reviews in Medicinal Chemistry
Title: Antibiotics which Target the Wolbachia Endosymbionts of Filarial Parasites: A New Strategy for Control of Filariasis and Amelioration of Pathology
Volume: 6 Issue: 2
Author(s): K. M. Pfarr and A. M. Hoerauf
Affiliation:
Keywords: Lymphatic filariasis, onchocerciasis, Wolbachia, tetracycline, doxycycline
Abstract: Wolbachia endosymbionts of filariae are targets for the development of new antifilarial chemotherapy. Doxycycline to deplete Wolbachia from the worm has demonstrated the feasibility of this strategy and has provided a new chemotherapeutic tool. Recent research shows that depleting Wolbachia will also lessen pathology, and lessen adverse reactions to traditional antifilarial drugs.
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Cite this article as:
Pfarr M. K. and Hoerauf M. A., Antibiotics which Target the Wolbachia Endosymbionts of Filarial Parasites: A New Strategy for Control of Filariasis and Amelioration of Pathology, Mini-Reviews in Medicinal Chemistry 2006; 6 (2) . https://dx.doi.org/10.2174/138955706775475984
DOI https://dx.doi.org/10.2174/138955706775475984 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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