Synthesis and Evaluation of Aminoglycosides as Inhibitors for Rev binding to Rev Responsive Element

Title: Synthesis and Evaluation of Aminoglycosides as Inhibitors for Rev binding to Rev Responsive Element

Volume: 3 Issue: 2

Author(s): Hayamitsu Adachi, Yoshinori Takahashi, Motoki Kyo, Tsuyoshi Sato and Yoshio Nishimura

Affiliation:

Keywords: Aminoglycoside, surface plasmon resonance imaging, RNA recognition

Abstract: Interactions of α-amino or guanidino-α-hydroxybutyryl-aminoglycosides with an essential sequence of Rev responsive element (RRE) in HIV-1 mRNA were evaluated using surface plasmon resonance imaging. Aminoglycosides were proved to bind nonspecifically to RRE.

Cite this article as:

Adachi Hayamitsu, Takahashi Yoshinori, Kyo Motoki, Sato Tsuyoshi and Nishimura Yoshio, Synthesis and Evaluation of Aminoglycosides as Inhibitors for Rev binding to Rev Responsive Element, Letters in Drug Design & Discovery 2006; 3 (2) . https://dx.doi.org/10.2174/157018006775789694