Synthesis, Characterization and Biological Activity of Chemically Modified Insulin Derivative with Alpha Lipoic Acid

Title: Synthesis, Characterization and Biological Activity of Chemically Modified Insulin Derivative with Alpha Lipoic Acid

Volume: 13 Issue: 2

Author(s): Tao Huang and Kaixun Huang

Affiliation:

Keywords: Insulin, α-lipoic acid, chemical modification, lipoyl-insulin, monolipoyl-insulin

Abstract: A novel chemically-modified insulin, ε-NB29-lipoyl insulin, was selectively prepared by the covalent linkage of α-lipoic acid (LA) to the ε-amino group of LysB29 of insulin without any protecting agent and analyzed by PAGE, HPLC, MALDI-TOF-MS. Monolipoyl- insulin maintained the glucose-lowering effect as well as native insulin and showed A longer duration of action than native insulin and an inhibitory effect towards trypsin degradation.

Cite this article as:

Huang Tao and Huang Kaixun, Synthesis, Characterization and Biological Activity of Chemically Modified Insulin Derivative with Alpha Lipoic Acid, Protein & Peptide Letters 2006; 13 (2) . https://dx.doi.org/10.2174/092986606775101599