Abstract
During the past two decades, many pharmacological strategies have been investigated for the management of painful neuropathies. However, neuropathic pain still remains a clinical challenge. A combination of therapies is often required, but unfortunately in most cases adequate pain relief is not achieved. Recently, attention has been focused on the physiological and pharmacological effects of L-acetylcarnitine in neurological disorders. There are a number of reports indicating that L-acetylcarnitine can be considered as a therapeutic agent in neuropathic disorders including painful peripheral neuropathies. In this review article, we will examine the antinociceptive and the neuroprotective effects of Lacetylcarnitine as tested in clinical studies and in animal models of nerve injury.
Keywords: L-acetylcarnitine, neuropathic pain, peripheral neuropathies, antinociception
Current Neuropharmacology
Title: L-Acetylcarnitine: A Proposed Therapeutic Agent for Painful Peripheral Neuropathies
Volume: 4 Issue: 3
Author(s): S. Chiechio, A. Copani, F. Nicoletti and R. W. Gereau IV
Affiliation:
Keywords: L-acetylcarnitine, neuropathic pain, peripheral neuropathies, antinociception
Abstract: During the past two decades, many pharmacological strategies have been investigated for the management of painful neuropathies. However, neuropathic pain still remains a clinical challenge. A combination of therapies is often required, but unfortunately in most cases adequate pain relief is not achieved. Recently, attention has been focused on the physiological and pharmacological effects of L-acetylcarnitine in neurological disorders. There are a number of reports indicating that L-acetylcarnitine can be considered as a therapeutic agent in neuropathic disorders including painful peripheral neuropathies. In this review article, we will examine the antinociceptive and the neuroprotective effects of Lacetylcarnitine as tested in clinical studies and in animal models of nerve injury.
Export Options
About this article
Cite this article as:
Chiechio S., Copani A., Nicoletti F. and Gereau IV W. R., L-Acetylcarnitine: A Proposed Therapeutic Agent for Painful Peripheral Neuropathies, Current Neuropharmacology 2006; 4 (3) . https://dx.doi.org/10.2174/157015906778019509
DOI https://dx.doi.org/10.2174/157015906778019509 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Editorial [Hot topic: Progress and Prospects of Human Pluripotent Stem Cell Research(Guest Editor: Chunhui Xu)]
Current Stem Cell Research & Therapy Nanowired Drug Delivery to Enhance Neuroprotection in Spinal Cord Injury
CNS & Neurological Disorders - Drug Targets The Surgical Management of Parkinson's Disease
CNS & Neurological Disorders - Drug Targets Conference Report: 12<sup>th</sup> International Congress on Neuroprotective Agents (ICNA), Charlottesville, VA, USA September 28, 2014-Ocobert 01, 2014
CNS & Neurological Disorders - Drug Targets Stem Cell-Derived Motor Neurons: Applications and Challenges in Amyotrophic Lateral Sclerosis
Current Stem Cell Research & Therapy Melatonin Synthetic Analogs as Nitric Oxide Synthase Inhibitors
Mini-Reviews in Medicinal Chemistry Regulatory Cascade of Neuronal Loss and Glucose Metabolism
CNS & Neurological Disorders - Drug Targets Non-Celiac Gluten Sensitivity Triggers Gut Dysbiosis, Neuroinflammation, Gut-Brain Axis Dysfunction, and Vulnerability for Dementia
CNS & Neurological Disorders - Drug Targets Ultra-micronized Palmitoylethanolamide Effects on Sleep-wake Rhythm and Neuropathic Pain Phenotypes in Patients with Carpal Tunnel Syndrome: An Open-label, Randomized Controlled Study
CNS & Neurological Disorders - Drug Targets Neuroimaging of Non-Accidental Injury
Current Pediatric Reviews Pleiotrophin as a Possible New Target for Angiogenesis-Related Diseases and Cancer
Recent Patents on Anti-Cancer Drug Discovery Peripheral and Central Mechanisms of Inflammatory Pain, with Emphasis on MAP Kinases
Current Drug Targets - Inflammation & Allergy Gelatin-Siloxane Hybrid Scaffolds with Vascular Endothelial Growth Factor Induces Brain Tissue Regeneration
Current Neurovascular Research Involvement of Tachykinins in Intestinal Inflammation
Current Pharmaceutical Design Potential of Bone Marrow Stromal Cells in Applications for Neuro-Degenerative, Neuro-Traumatic and Muscle Degenerative Diseases
Current Neuropharmacology Expression and Function of the Endocannabinoid System in Glial Cells
Current Pharmaceutical Design Subject Index to Volume 2
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Recent Advances in the Use of Algal Polysaccharides for Skin Wound Healing
Current Pharmaceutical Design Selection of Potential Pharmacological Targets in ALS Based on Whole- Genome Expression Profiling
Current Medicinal Chemistry Gene Expression Profiling in Rodent Models for Schizophrenia
Current Neuropharmacology