Abstract
Identification of high-risk atherosclerotic lesions prone to rupture and thrombosis may greatly decrease the morbidity and mortality associated with atherosclerosis. High-resolution magnetic resonance imaging (MRI) has recently emerged as one of the most promising techniques for the noninvasive study of atherothrombotic disease, as it can characterize plaque composition and monitor its progression. The development of MRI contrast agents that specifically target components of the atherosclerotic plaque may enable non-invasive detection of high-risk lesions. This review discusses the use of high-resolution MRI for plaque detection and characterization and the potentials of Molecular Imaging using a variety of molecules present in atherosclerotic plaques that may serve as targets for specific contrast agents to allow the identification of high-risk atherosclerotic lesions invivo. Ultimately, such agents may enable treatment of high-risk patients prior to lesion progression and occurrence of complications.
Keywords: Atherosclerosis, magnetic resonance imaging, coronary artery disease
Current Molecular Medicine
Title: Plaque Imaging and Characterization Using Magnetic Resonance Imaging: Towards Molecular Assessment
Volume: 6 Issue: 5
Author(s): Marc Sirol, Valentin Fuster and Zahi A. Fayad
Affiliation:
Keywords: Atherosclerosis, magnetic resonance imaging, coronary artery disease
Abstract: Identification of high-risk atherosclerotic lesions prone to rupture and thrombosis may greatly decrease the morbidity and mortality associated with atherosclerosis. High-resolution magnetic resonance imaging (MRI) has recently emerged as one of the most promising techniques for the noninvasive study of atherothrombotic disease, as it can characterize plaque composition and monitor its progression. The development of MRI contrast agents that specifically target components of the atherosclerotic plaque may enable non-invasive detection of high-risk lesions. This review discusses the use of high-resolution MRI for plaque detection and characterization and the potentials of Molecular Imaging using a variety of molecules present in atherosclerotic plaques that may serve as targets for specific contrast agents to allow the identification of high-risk atherosclerotic lesions invivo. Ultimately, such agents may enable treatment of high-risk patients prior to lesion progression and occurrence of complications.
Export Options
About this article
Cite this article as:
Sirol Marc, Fuster Valentin and Fayad A. Zahi, Plaque Imaging and Characterization Using Magnetic Resonance Imaging: Towards Molecular Assessment, Current Molecular Medicine 2006; 6 (5) . https://dx.doi.org/10.2174/156652406778018617
DOI https://dx.doi.org/10.2174/156652406778018617 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Nanotechnology and Applied Combustion: Use of Nanostructured Materials for Light-Activated Distributed Ignition of Fuels with Propulsion Applications
Recent Patents on Space Technology Hypoxia Signaling and the Metastatic Phenotype
Current Molecular Medicine Human β-secretase (BACE) and BACE Inhibitors: Progress Report
Current Topics in Medicinal Chemistry Decrease in the Generation of Amyloid-β Due to Salvianolic Acid B by Modulating BACE1 Activity
Current Alzheimer Research Inflammation and Arterial Hypertension: From Pathophysiological Links to Risk Prediction
Current Medicinal Chemistry Isoprostanes as Biomarkers and Mediators of Oxidative Injury in Infant and Adult Central Nervous System Diseases
Current Neurovascular Research Pancreastatin, A Regulatory Peptide that Modulates Energy Metabolism
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents The Therapeutic Potential of Induced Pluripotent Stem Cells After Stroke: Evidence from Rodent Models
Current Stem Cell Research & Therapy The Importance of Fracture Liaison Services to the Healthcare System: A Review
Current Rheumatology Reviews Efficacy of Lopinavir/Ritonavir Compared With Standard Care for Treatment of Coronavirus Disease 2019 (COVID-19): A Systematic Review
Infectious Disorders - Drug Targets Protein-Protein Interactions in Drug Discovery
Drug Design Reviews - Online (Discontinued) Commentary: Low-Grade Non-Resolving Neuroinflammation: Age Does Matter
CNS & Neurological Disorders - Drug Targets Antiplatelet for Coronary Artery Disease in Specific Condition “No Size Fits All”
Current Pharmaceutical Design Appraisal of Felodipine Nanocrystals for Solubility Enhancement and Pharmacodynamic Parameters on Cadmium Chloride Induced Hypertension in Rats
Current Drug Delivery Genomics and Pharmacogenomics of Salt-sensitive Hypertension
Current Hypertension Reviews Antiplatelet Treatment in Ischemic Stroke Treatment
Current Topics in Medicinal Chemistry Cholesterol and LDL Relate to Neuritic Plaques and to APOE4 Presence but Not to Neurofibrillary Tangles
Current Alzheimer Research Cerebral White Matter Lesions, Risk of Stroke and Cerebrovascular Protection with Angiotensin Receptor Blockers
Current Drug Therapy Cloud-Point Extraction Coupled with High-Performance Liquid Chromatography for the Determination and Pharmacokinetic Study of Dipyridamole in Rat Plasma
Current Pharmaceutical Analysis Vasopressin and Oxytocin in Control of the Cardiovascular System
Current Neuropharmacology