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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Analysing the Output from Primary Screening

Author(s): Dawn Nowlin, Patrick Bingham, Andrew Berridge, Philip Gribbon, Philip Laflin and Andreas Sewing

Volume 9, Issue 5, 2006

Page: [331 - 337] Pages: 7

DOI: 10.2174/138620706777452401

Price: $65

Abstract

From a perspective of process knowledge and enhancement, the analysis of the results of biological screening should not be limited to the outcome of specific projects, but additionally encompass a process centric view. Summarising outcomes across multiple projects is a powerful tool to gain a greater understanding of biological screening that will also enable optimisation of the strategy for specific projects or target classes. We have analysed a set of 73651 compounds with reproducible (confirmed) results from 63 high-throughput screening (HTS) campaigns to reveal the underlying trends in the population of active compounds. We have focused on the overall physico-chemical profile of compound populations derived from biological screening since the in vivo activity of drug molecules is the result of physicochemical and structural properties of the compound.

Keywords: high-throughput screening (HTS), Oxaprozin, compound aggregation, SEQUENCE ANALYSIS, drug discovery

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