Abstract
How organismal complexity is achieved is a fundamental biological issue. The surprising revelation that complex eukaryotes have fewer than expected genes presents an important challenge for deciphering how organisms achieve complexity. The genome size and the gene number do not necessarily correlate in a consistent manner with the perceived organismal complexity. In this review, we focus on known molecular mechanisms that increase genetic complexity at the molecular and functional levels, and discuss features that have likely contributed to organismal complexity.
Keywords: TATA-binding protein (TBP), bacterial operons, ubiquitin, transcriptome, Somatic recombination, Polyadenylation
Current Genomics
Title: Building Biological Complexity with Limited Genes
Volume: 7 Issue: 2
Author(s): Ravinder Singh, Mark D. Robida and Sina Karimpour
Affiliation:
Keywords: TATA-binding protein (TBP), bacterial operons, ubiquitin, transcriptome, Somatic recombination, Polyadenylation
Abstract: How organismal complexity is achieved is a fundamental biological issue. The surprising revelation that complex eukaryotes have fewer than expected genes presents an important challenge for deciphering how organisms achieve complexity. The genome size and the gene number do not necessarily correlate in a consistent manner with the perceived organismal complexity. In this review, we focus on known molecular mechanisms that increase genetic complexity at the molecular and functional levels, and discuss features that have likely contributed to organismal complexity.
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Cite this article as:
Singh Ravinder, Robida D. Mark and Karimpour Sina, Building Biological Complexity with Limited Genes, Current Genomics 2006; 7 (2) . https://dx.doi.org/10.2174/138920206777304669
DOI https://dx.doi.org/10.2174/138920206777304669 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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