Abstract
Functional divergence after gene duplications is a fundamental issue for functional innovations in many organisms. As gene family proliferation (gene duplication) may have provided the raw materials for the origin of new genes, the details of how duplicate genes have preserved through functional divergence remain largely unknown. In this review paper, we discuss some recent developments about this important issue, with special references to the implication for functional genomics. With a combination of large-scale genome sequencing and powerful computational analysis, we show a great deal of functional information can be obtained from the evolutionary perspective, which can in turn be used to facilitate high throughput functional assays. The software DIVERGE can be obtained form http://xgu.gdcb.iastate.edu.
Keywords: Vertebrate Mitochondrial Genomes, Amino Acid Residues, JAK Proteins, Mitochondria Genes, caspases, Cluster-Specific Functional Divergence
Current Genomics
Title: Predicting Type-I (Rate-Shift) Functional Divergence of Protein Sequences and Applications in Functional Genomics
Volume: 7 Issue: 2
Author(s): Xun Gu, Yufeng Wang, Jianying Gu, Kent V. Velden and Dongping Xu
Affiliation:
Keywords: Vertebrate Mitochondrial Genomes, Amino Acid Residues, JAK Proteins, Mitochondria Genes, caspases, Cluster-Specific Functional Divergence
Abstract: Functional divergence after gene duplications is a fundamental issue for functional innovations in many organisms. As gene family proliferation (gene duplication) may have provided the raw materials for the origin of new genes, the details of how duplicate genes have preserved through functional divergence remain largely unknown. In this review paper, we discuss some recent developments about this important issue, with special references to the implication for functional genomics. With a combination of large-scale genome sequencing and powerful computational analysis, we show a great deal of functional information can be obtained from the evolutionary perspective, which can in turn be used to facilitate high throughput functional assays. The software DIVERGE can be obtained form http://xgu.gdcb.iastate.edu.
Export Options
About this article
Cite this article as:
Gu Xun, Wang Yufeng, Gu Jianying, Velden V. Kent and Xu Dongping, Predicting Type-I (Rate-Shift) Functional Divergence of Protein Sequences and Applications in Functional Genomics, Current Genomics 2006; 7 (2) . https://dx.doi.org/10.2174/138920206777304623
DOI https://dx.doi.org/10.2174/138920206777304623 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
miR-21 and let-7 in the Ras and NF-κB Pathways
MicroRNA The Role of JNK Signalling in Responses to Oxidative DNA Damage
Current Drug Targets Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers
Current Cancer Drug Targets Procyanidin B2 3,3″-di-O-gallate Inhibits Endothelial Cells Growth and Motility by Targeting VEGFR2 and Integrin Signaling Pathways
Current Cancer Drug Targets Gene Therapy in In Vivo Isolated Perfusion Models
Current Gene Therapy Pharmacogenetics of Childhood Acute Lymphoblastic Leukemia
Current Pharmacogenomics Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer
Current Topics in Medicinal Chemistry Targeting MDM4 as a Novel Therapeutic Approach for Hematologic Malignancies
Current Cancer Drug Targets Natural History of Ulcerative Colitis: Current Knowledge
Current Drug Targets Chemoprevention Gene Therapy (CGT): Novel Combinatorial Approach for Preventing and Treating Pancreatic Cancer
Current Molecular Medicine Connecting A Tumor to the Environment
Current Pharmaceutical Design Pharmacological Inhibitors of NAD Biosynthesis as Potential An ticancer Agents
Recent Patents on Anti-Cancer Drug Discovery Editorial [Hot Topic: Targeted Therapies for Pancreatic Cancer Executive (Guest Editor: Qingyong Ma)]
Current Pharmaceutical Design β-lactam Functionalized Poly(isoprene-b-ethylene oxide) Amphiphilic Block Copolymer Micelles as a New Nanocarrier System for Curcumin
Current Nanoscience Methionine Aminopeptidases as Potential Targets for Treatment of Gastrointestinal Cancers and other Tumors
Current Drug Targets Promotion of Apoptosis in Cancer Cells by Selective Purine-Derived Pharmacological CDK Inhibitors: One Outcome, Many Mechanisms
Current Pharmaceutical Design Withdrawal Notice: Role of MicroRNAs (224 and 96) as Novel Biomarkers for Hepatocellular Carcinoma
Current Cancer Therapy Reviews Computer-Aided Drug Design for Cancer-Causing H-Ras p21 Mutant Protein
Letters in Drug Design & Discovery Topical Antimicrobials for Burn Wound Infections
Recent Patents on Anti-Infective Drug Discovery KIR Molecules: Recent Patents of Interest for the Diagnosis and Treatment of Several Autoimmune Diseases, Chronic Inflammation, and B-cell Malignancies
Recent Patents on DNA & Gene Sequences