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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Theory of Substituent Effects: Recent Advances

Author(s): O. Exner and S. Bohm

Volume 10, Issue 7, 2006

Page: [763 - 778] Pages: 16

DOI: 10.2174/138527206776818892

Price: $65

Abstract

The review reports recent progress in the studies of substituent effects in isolated molecules, i. e. based either on the experimental gas-phase acidities (basicities), or on quantum chemical calculations. Attention was focused on cases when the results differed from or exceeded the traditional views: redefinition of the inductive effect, quantitative estimation of resonance, validity of the Hammett equation, interpretation of the ortho effect, additivity of the enthalpies of formation, acidity of carboxylic acids.

Keywords: basicities, Gas-Phase Acidities, Enthalpy, Quantum Chemical Calculations, Inductive Effect


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