Abstract
The insulin-like growth factor (IGF) system involves a complex network of ligands (IGF-I and IGF-II), receptors (IGF-1R and IGF-2R), IGF-binding proteins (IGFBP-1 to IGFBP-6), and downstream intracellular signaling elements. The IGF-axis modulates proliferation and (anti-)apoptosis in mammals, and it is therefore not surprising that dysregulation of different pathway components is involved in the development and progression of several tumor entities such as breast, prostate, lung, and liver cancer. Because IGFs, IGF-receptors, and IGFBPs play a critical role in the emergence of human neoplasias, these molecules have become the center of special interest as prime targets for potential anti-cancer therapies. In the last decade, various substances and experimental strategies, which affect the IGF-induced signal transduction, have successfully been used in treatment of neoplasias in vitro and in vivo. These approaches contain neutralizing antibodies, antagonistic peptides, selective receptor kinase inhibitors, and (antisense-)oligonucleotides.
Keywords: Insulin-like growth factor, therapy, IGF-1R, cancer
Current Cancer Therapy Reviews
Title: The Insulin-Like Growth Factor (IGF) Signaling Pathway: Strategies for Successful Therapeutic Tasks in Cancer Treatment
Volume: 2 Issue: 2
Author(s): Kai Breuhahn, Tanja Nussbaum, Stephan Singer and Peter Schirmacher
Affiliation:
Keywords: Insulin-like growth factor, therapy, IGF-1R, cancer
Abstract: The insulin-like growth factor (IGF) system involves a complex network of ligands (IGF-I and IGF-II), receptors (IGF-1R and IGF-2R), IGF-binding proteins (IGFBP-1 to IGFBP-6), and downstream intracellular signaling elements. The IGF-axis modulates proliferation and (anti-)apoptosis in mammals, and it is therefore not surprising that dysregulation of different pathway components is involved in the development and progression of several tumor entities such as breast, prostate, lung, and liver cancer. Because IGFs, IGF-receptors, and IGFBPs play a critical role in the emergence of human neoplasias, these molecules have become the center of special interest as prime targets for potential anti-cancer therapies. In the last decade, various substances and experimental strategies, which affect the IGF-induced signal transduction, have successfully been used in treatment of neoplasias in vitro and in vivo. These approaches contain neutralizing antibodies, antagonistic peptides, selective receptor kinase inhibitors, and (antisense-)oligonucleotides.
Export Options
About this article
Cite this article as:
Breuhahn Kai, Nussbaum Tanja, Singer Stephan and Schirmacher Peter, The Insulin-Like Growth Factor (IGF) Signaling Pathway: Strategies for Successful Therapeutic Tasks in Cancer Treatment, Current Cancer Therapy Reviews 2006; 2 (2) . https://dx.doi.org/10.2174/157339406776872861
DOI https://dx.doi.org/10.2174/157339406776872861 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Gold Nanoparticle-Based Drug Delivery Platform for Antineoplastic Chemotherapy
Current Drug Metabolism Acute and Sub-chronic Toxicity Analyses of Hot-Water Extract of Isaria japonica from Silkworm (Bombyx mori) Pupae
Current Traditional Medicine Artificial Intelligence, Big Data and Machine Learning Approaches in Precision Medicine & Drug Discovery
Current Drug Targets A Novel Fusicoccin Derivative Preferentially Targets Hypoxic Tumor Cells and Inhibits Tumor Growth in Xenografts
Anti-Cancer Agents in Medicinal Chemistry Role of Hsp70 in Cancer Growth and Survival
Protein & Peptide Letters Younger for Longer: Insulin Signalling, Immunity and Ageing
Current Aging Science Quantitative Ultrasound in Diagnosis of Metabolic Bone Diseases
Current Medical Imaging Targeting MUC15 Protein in Cancer: Molecular Mechanisms and Therapeutic Perspectives
Current Cancer Drug Targets Receptor Tyrosine Kinases: The Main Targets for New Anticancer Therapy
Current Drug Targets Functionalized Silver Nanoparticles for Sensing, Molecular Imaging and Therapeutic Applications
Current Nanomedicine Mechanisms of Tumor Cell Necrosis
Current Pharmaceutical Design Naturally Occurring and Synthetic Bioactive Molecules as Novel Non-Nucleoside HBV Inhibitors
Mini-Reviews in Medicinal Chemistry Molecular Bases of Chemoresistance in Cholangiocarcinoma
Current Drug Targets Total Polyphenols and Bioactivity of Seeds and Sprouts in Several Legumes
Current Pharmaceutical Design New Drugs, Therapeutic Strategies, and Future Direction for the Treatment of Pulmonary Arterial Hypertension
Current Medicinal Chemistry Role of Alterations in the Apoptotic Machinery in Sensitivity of Cancer Cells to Treatment
Current Pharmaceutical Design Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action
Current Topics in Medicinal Chemistry Acute Myeloid Leukemia in the Elderly: Current Therapeutic Results and Perspectives for Clinical Research
Reviews on Recent Clinical Trials Editorial (Hot Topic: Novel Aspects of Apoptosis Modulating Drugs)
Current Pharmaceutical Biotechnology Fibrinogen Alpha Chain Acts as a HBsAg Binding Protein and their Interaction Promotes HepG2 Cell Apoptosis
Current Proteomics