Abstract
Since the discovery of artificially produced radioisotopes in the 1930s, an estimated 10-12 million nuclear medicine diagnostic and therapeutic procedures are currently performed each year only in the United States. Gamma emission imaging has been successfully applied to almost every organ of the body (brain, bone, heart, kidney, lung, neuroreceptors) as well as sites of inflammation, atherosclerosis, and thrombosis. FDG-PET has been used in some of the inflammatory diseases as well. On the other hand, both alpha and beta-emitting isotopes have been evaluated for brachytherapy of rheumatoid diseases, each with different radiobiological effectiveness. The current status of radionuclides for imaging, therapy and research studies of inflammatory processes is reviewed here and a look into the future directions is described at the conclusion.
Keywords: Inflammation, radiopharmaceuticals, diagnosis, therapy, SPECT, PET, NSAID, FUO
Current Medicinal Chemistry
Title: Application of Radioisotopes in Inflammation
Volume: 13 Issue: 8
Author(s): A. R. Jalilian, M. Bineshmarvasti and S. Sardari
Affiliation:
Keywords: Inflammation, radiopharmaceuticals, diagnosis, therapy, SPECT, PET, NSAID, FUO
Abstract: Since the discovery of artificially produced radioisotopes in the 1930s, an estimated 10-12 million nuclear medicine diagnostic and therapeutic procedures are currently performed each year only in the United States. Gamma emission imaging has been successfully applied to almost every organ of the body (brain, bone, heart, kidney, lung, neuroreceptors) as well as sites of inflammation, atherosclerosis, and thrombosis. FDG-PET has been used in some of the inflammatory diseases as well. On the other hand, both alpha and beta-emitting isotopes have been evaluated for brachytherapy of rheumatoid diseases, each with different radiobiological effectiveness. The current status of radionuclides for imaging, therapy and research studies of inflammatory processes is reviewed here and a look into the future directions is described at the conclusion.
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Cite this article as:
Jalilian R. A., Bineshmarvasti M. and Sardari S., Application of Radioisotopes in Inflammation, Current Medicinal Chemistry 2006; 13 (8) . https://dx.doi.org/10.2174/092986706776361049
DOI https://dx.doi.org/10.2174/092986706776361049 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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