Abstract
In the last decade much attention has been paid to the development of metabolically non-reversible dimeric or hybrid compounds, which combine two structural units of one or two lead compounds of interest for the treatment of Alzheimers disease. As a consequence of their capability to simultaneously interact with two binding sites of the same biological target (the enzyme acetylcholinesterase in most cases), to expand their interaction in the main binding site of the target molecule, or to interact with two different biological targets of interest in the pathogenesis of the disease, these dimeric or hybrid compounds exhibit an improved pharmacological profile including high affinity interactions, additional non conventional actions or complementary actions, what makes them potential drug candidates for the treatment of Alzheimers disease. Herein, we review from a structural point of view the main classes of dimeric or hybrid compounds developed for the treatment of Alzheimers disease, along with the pharmacological profile of the most active compounds.
Keywords: N-benzylpiperidines, homodimers, heterodimers, dual-site binding, extended binding, dual action
Current Medicinal Chemistry
Title: Dimeric and Hybrid Anti-Alzheimer Drug Candidates
Volume: 13 Issue: 4
Author(s): D. Munoz-Torrero and P. Camps
Affiliation:
Keywords: N-benzylpiperidines, homodimers, heterodimers, dual-site binding, extended binding, dual action
Abstract: In the last decade much attention has been paid to the development of metabolically non-reversible dimeric or hybrid compounds, which combine two structural units of one or two lead compounds of interest for the treatment of Alzheimers disease. As a consequence of their capability to simultaneously interact with two binding sites of the same biological target (the enzyme acetylcholinesterase in most cases), to expand their interaction in the main binding site of the target molecule, or to interact with two different biological targets of interest in the pathogenesis of the disease, these dimeric or hybrid compounds exhibit an improved pharmacological profile including high affinity interactions, additional non conventional actions or complementary actions, what makes them potential drug candidates for the treatment of Alzheimers disease. Herein, we review from a structural point of view the main classes of dimeric or hybrid compounds developed for the treatment of Alzheimers disease, along with the pharmacological profile of the most active compounds.
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Cite this article as:
Munoz-Torrero D. and Camps P., Dimeric and Hybrid Anti-Alzheimer Drug Candidates, Current Medicinal Chemistry 2006; 13 (4) . https://dx.doi.org/10.2174/092986706775527974
DOI https://dx.doi.org/10.2174/092986706775527974 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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