Abstract
Epidemiological studies have revealed an inverse correlation between the intake of cruciferous vegetables and the risk of certain types of cancer. In animal studies, results suggest that the anti-cancerous effect of cruciferous vegetables is due to isothiocyanates that exist as thioglucoside conjugates in a variety of edible plants, including broccoli cabbage for example. Among isothiocyanates (ITC), Sulforaphane (SF) has received a great deal of interest due to its potent anti-tumoral properties in carcinogen-treated animals. The molecular pathways mediating the effects of SF have not been fully elucidated. However, many studies have shown that SF (as well as other ITCs) can induce phase II drug metabolizing enzymes in vitro as well as in animals. This commonly occurs via the activation of a basic leucine zipper transcription factor, Nrf2. In addition, accumulating evidence now indicates that SF can inhibit the proliferation of cancer cells in culture through the induction of cell cycle arrest via the regulation of cell cycle protein levels and/or cyclindependent kinase activity, tubulin polymerization and histone acetylation. Furthermore, ITCs have been shown to induce apoptotic cell death via a P53 dependent or independent pathway. Here, it is proposed to review the different intracellular targets involved in the in vitro effects of SF in various cancer cell lines. The relationship will then be discussed that exists between the various cell signaling pathways involved in this effect, and finally, the important aspects will be identified that must be addressed to fully understand the exact mechanism of action of SF.
Keywords: Sulforaphane, cell cycle, apoptosis, signal transduction, Nrf2, reactive oxygen species
Current Cancer Drug Targets
Title: Signaling Pathways and Intracellular Targets of Sulforaphane Mediating Cell Cycle Arrest and Apoptosis
Volume: 6 Issue: 2
Author(s): L. Gamet-Payrastre
Affiliation:
Keywords: Sulforaphane, cell cycle, apoptosis, signal transduction, Nrf2, reactive oxygen species
Abstract: Epidemiological studies have revealed an inverse correlation between the intake of cruciferous vegetables and the risk of certain types of cancer. In animal studies, results suggest that the anti-cancerous effect of cruciferous vegetables is due to isothiocyanates that exist as thioglucoside conjugates in a variety of edible plants, including broccoli cabbage for example. Among isothiocyanates (ITC), Sulforaphane (SF) has received a great deal of interest due to its potent anti-tumoral properties in carcinogen-treated animals. The molecular pathways mediating the effects of SF have not been fully elucidated. However, many studies have shown that SF (as well as other ITCs) can induce phase II drug metabolizing enzymes in vitro as well as in animals. This commonly occurs via the activation of a basic leucine zipper transcription factor, Nrf2. In addition, accumulating evidence now indicates that SF can inhibit the proliferation of cancer cells in culture through the induction of cell cycle arrest via the regulation of cell cycle protein levels and/or cyclindependent kinase activity, tubulin polymerization and histone acetylation. Furthermore, ITCs have been shown to induce apoptotic cell death via a P53 dependent or independent pathway. Here, it is proposed to review the different intracellular targets involved in the in vitro effects of SF in various cancer cell lines. The relationship will then be discussed that exists between the various cell signaling pathways involved in this effect, and finally, the important aspects will be identified that must be addressed to fully understand the exact mechanism of action of SF.
Export Options
About this article
Cite this article as:
Gamet-Payrastre L., Signaling Pathways and Intracellular Targets of Sulforaphane Mediating Cell Cycle Arrest and Apoptosis, Current Cancer Drug Targets 2006; 6 (2) . https://dx.doi.org/10.2174/156800906776056509
DOI https://dx.doi.org/10.2174/156800906776056509 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
Call for Papers in Thematic Issues
Advances in Cancer Biomarkers and Potential Drug Targets: From Diagnosis to Therapy
Cancer biomarkers play a crucial role in the diagnosis, prognosis, and treatment of cancer. They provide valuable information for cancer detection, risk assessment, treatment selection, and monitoring response to therapy. With advancements in molecular biology and high-throughput technologies, there has been an increasing interest in identifying and characterizing cancer biomarkers ...read more
Novel Therapeutic Approaches to Target Drug Resistant Tumors
With the development of disciplines such as chemical biology and molecular biology, the genes or proteins closely related to tumor occurrence and development have gradually become clear. Targeted therapies targeting these genes or proteins provide more effective methods for tumor treatment. Tumor targeted drugs generally only act on specific targets ...read more
ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process to explore and investigate the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment
Immune system protects host against malignant tumors through effector cells and molecules. Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses cancer progression. Chronic inflammation facilitates cancer progression and treatment resistance, whereas induction of acute inflammatory reactions often lead to anti-cancer immune responses. ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Role of Anticoagulation in IPF
Current Respiratory Medicine Reviews Druggability of Mortalin for Cancer and Neuro-Degenerative Disorders
Current Pharmaceutical Design Identification of High-affinity Small Molecules Targeting Gamma Secretase for the Treatment of Alzheimer’s Disease
Current Topics in Medicinal Chemistry Synthetic Routes and Biological Activities of Benzofuran and its Derivatives: A Review
Letters in Organic Chemistry Resveratrol: A Therapeutic Promise for Cardiovascular Diseases
Recent Patents on Cardiovascular Drug Discovery Somatic Mutation Analyses in Studies of the Clonal Evolution and Diagnostic Targets of Prostate Cancer
Current Genomics Unfoldomics of Human Genetic Diseases: Illustrative Examples of Ordered and Intrinsically Disordered Members of the Human Diseasome
Protein & Peptide Letters D-RNAi (Messenger RNA-antisense DNA Interference) as a Novel Defense System Against Cancer and Viral Infections.
Current Cancer Drug Targets Dual Anti-cancer and Anti-Itch Activity of PD176252 Analogues: Design, Synthesis and Biological Evaluation
Anti-Cancer Agents in Medicinal Chemistry Possible Mechanisms for Tumour Cell Sensitivity to TNF-a and Potential Therapeutic Applications
Current Pharmaceutical Biotechnology Population Pharmacokinetic Evaluation of a Fully Human IgG2 Monoclonal Antibody in Patients with Inflammatory Diseases
Inflammation & Allergy - Drug Targets (Discontinued) New Advances in the Pathogenesis and Progression of Barrett’s Esophagus
Current Molecular Medicine Steroid Receptor-Associated Immunophilins: Candidates for Diverse Drug-Targeting Approaches in Disease
Current Molecular Pharmacology Developments Towards a Prophylactic Hepatitis C Virus Vaccine
Current Immunology Reviews (Discontinued) Challenges and Opportunities from Basic Cancer Biology for Nanomedicine for Targeted Drug Delivery
Current Cancer Drug Targets Targeting Strategies in Therapeutic Applications of Toxoplasmosis: Recent Advances in Liposomal Vaccine Delivery Systems
Current Drug Targets <i>In Vitro</i> Protective Potentials of <i>Annona muricata</i> Leaf Extracts Against Sodium Arsenite-induced Toxicity
Current Drug Discovery Technologies HLA-G - From Fetal Tolerance to a Regulatory Molecule in Inflammatory Diseases
Current Immunology Reviews (Discontinued) Editorial from Guest Editor (Thematic Issue: Current Approach to COPD Management: Setting a Model in Medical Therapeutics)
Current Respiratory Medicine Reviews Signaling Through Rho GTPase Pathway as Viable Drug Target
Current Medicinal Chemistry