Abstract
Diabetes mellitus type 2 is a metabolic disease associated with chronic hyperglycaemia, which leads to a wide range of complications, including microvascular and macrovascular alterations, retinopathy, nephropathy and renal disease or peripheral neuropathy. Several intracellular pathways have been shown to be associated to type 2 diabetes mellitus, ranging from an altered insulin receptor-associated signalling to an abnormal intracellular calcium homeostasis or disturbances in Na+ handling. A number of diabetes-associated complications have been reported to be associated with hyperactivity of certain protein tyrosine kinases, such as those cytosolic kinases of the Src family, involved in the altered intracellular calcium mobilisation and platelet-derived cardiovascular problems and in glomerular injury, or the JAK family of tyrosine kinases involved in hyperglycaemia-induced renal failure. There has been a considerable effort in several laboratories to identify suitable targets for the design of drugs against this disease. The development of tyrosine kinase inhibitors suitable for medical purposes might represent a significant advance in the therapy of complications associated to type 2 diabetes mellitus.
Keywords: Type 2 diabetes mellitus, calcium homeostasis, tyrosine kinases
Current Enzyme Inhibition
Title: Roles of Calcium and Tyrosine Kinases in the Pathogenesis of Type 2 Diabetes Mellitus
Volume: 2 Issue: 1
Author(s): J. A. Rosado, P. C. Redondo, J. A. Pariente and G. M. Salido
Affiliation:
Keywords: Type 2 diabetes mellitus, calcium homeostasis, tyrosine kinases
Abstract: Diabetes mellitus type 2 is a metabolic disease associated with chronic hyperglycaemia, which leads to a wide range of complications, including microvascular and macrovascular alterations, retinopathy, nephropathy and renal disease or peripheral neuropathy. Several intracellular pathways have been shown to be associated to type 2 diabetes mellitus, ranging from an altered insulin receptor-associated signalling to an abnormal intracellular calcium homeostasis or disturbances in Na+ handling. A number of diabetes-associated complications have been reported to be associated with hyperactivity of certain protein tyrosine kinases, such as those cytosolic kinases of the Src family, involved in the altered intracellular calcium mobilisation and platelet-derived cardiovascular problems and in glomerular injury, or the JAK family of tyrosine kinases involved in hyperglycaemia-induced renal failure. There has been a considerable effort in several laboratories to identify suitable targets for the design of drugs against this disease. The development of tyrosine kinase inhibitors suitable for medical purposes might represent a significant advance in the therapy of complications associated to type 2 diabetes mellitus.
Export Options
About this article
Cite this article as:
Rosado A. J., Redondo C. P., Pariente A. J. and Salido M. G., Roles of Calcium and Tyrosine Kinases in the Pathogenesis of Type 2 Diabetes Mellitus, Current Enzyme Inhibition 2006; 2 (1) . https://dx.doi.org/10.2174/157340806775473553
DOI https://dx.doi.org/10.2174/157340806775473553 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Increased Rates of Coronary Artery Calcium Score in Patients with Non - Functioning Adrenal Incidentaloma
Endocrine, Metabolic & Immune Disorders - Drug Targets Identifying Risk Factors for Clinically Significant Diabetic Macula Edema in Patients with Type 2 Diabetes Mellitus
Current Diabetes Reviews UHPLC Quantitation Method for New Thiazolidinedione LPSF/GQ-02 and In Vitro/In Vivo Kinetic Studies
Drug Metabolism Letters A Perspective on Clinical Islet Transplantation: Past, Present and Developments for Future
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Effects of Maternal Obesity and Gestational Diabetes Mellitus on the Placenta: Current Knowledge and Targets for Therapeutic Interventions
Current Vascular Pharmacology Vascular Risk Factors and Alzheimer’s Disease Pathogenesis: Are Conventional Pharmacological Approaches Protective For Cognitive Decline Progression?
CNS & Neurological Disorders - Drug Targets Hip but Not Thigh Intramuscular Adipose Tissue is Associated with Poor Balance and Increased Temporal Gait Variability in Older Adults
Current Aging Science Pathophysiology and Therapeutics of Cardiovascular Disease in Metabolic Syndrome
Current Pharmaceutical Design Treatment of Diabetic Foot Ulcers
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Nutritional Modulation of Terminal End Buds: Its Relevance to Breast Cancer Prevention
Current Cancer Drug Targets Immune-Mediated Mechanisms in Atherosclerosis: Prevention and Treatment of Clinical Manifestations
Current Pharmaceutical Design Carotenoids and Cardiovascular Risk
Current Pharmaceutical Design Outcomes of Perilla Seed Oil as an Additional Neuroprotective Therapy in Patients with Mild to Moderate Dementia: A Randomized Control Trial
Current Alzheimer Research The Connection Between C-Reactive Protein (CRP) and Diabetic Vasculopathy. Focus on Preclinical Findings
Current Diabetes Reviews Metabolomic Insight into Lipid and Protein Profile in Diabetes Using Mass Spectrometry
Mini-Reviews in Medicinal Chemistry Circulating Cellular Players in Vascular Calcification
Current Pharmaceutical Design Diabetes Mellitus and Male Aging: Pharmacotherapeutics and Clinical Implications
Current Pharmaceutical Design Development and Clinical use of Prasugrel and Ticagrelor
Current Pharmaceutical Design Rho-Kinase and RGS-Containing RhoGEFs as Molecular Targets for the Treatment of Erectile Dysfunction
Current Pharmaceutical Design Preparation and Characterization of Glipizide Loaded Eudragit Microparticles
Micro and Nanosystems