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Review Article

Adipocyte Fatty Acid Binding Protein (A-FABP) as a Potential New Therapeutic Target for the Treatment of Obesity - Associated Cancers

Author(s): Kinga Majchrzak*, Marta Piotrowska, Julia Krajewska and Jakub Fichna

Volume 23, Issue 6, 2022

Published on: 12 July, 2021

Page: [597 - 605] Pages: 9

DOI: 10.2174/1389450122666210712193654

Price: $65

Abstract

Fatty acid binding protein A (A-FABP) is one of FABPs isoforms found mainly in adipose tissue and macrophages. It works through many integrated pathways, regulating inflammation and lipid metabolism, promoting glucose production, impairing insulin function, and contributing to diseases such as atherosclerosis and diabetes. A-FABP is upregulated in the adipose tissue of obese patients and its increased release into the bloodstream is positively associated with body mass index. Consequently, A-FABP plays a key role in regulating metabolism in obese people. Recent studies in mouse models and humans demonstrated the role of A-FABP in increasing the risk of obesity-related cancers. Here we summarized the state of research on the link between obesity, cancer and A-FABP as a new potential therapeutic target for the treatment of obesity - associated cancers.

Keywords: Fatty acid binding proteins, adipocytes, cancer, obesity, metabolic syndrome, metabolism.

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