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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

New Perspectives in Drug Delivery Systems for the Treatment of Tuberculosis

Author(s): Joandra Maísa da Silva Leite*, Yuri Basilio Gomes Patriota , Mônica Felts de La Roca and José Lamartine Soares-Sobrinho

Volume 29, Issue 11, 2022

Published on: 24 August, 2021

Page: [1936 - 1958] Pages: 23

DOI: 10.2174/0929867328666210629154908

Price: $65

Abstract

Background: Tuberculosis is a chronic respiratory disease caused by Mycobacterium tuberculosis. The common treatment regimens of tuberculosis are lengthy with adverse side effects, low patient compliance, and antimicrobial resistance. Drug delivery systems (DDSs) can overcome these limitations.

Objective: This review aims to summarize the latest DDSs for the treatment of tuberculosis. In the first section, the main pharmacokinetic and pharmacodynamic challenges posed by the innate properties of the drugs are put forth. The second section elaborates on the use of DDS to overcome the disadvantages of the current treatment of tuberculosis.

Conclusion: We reviewed research articles published in the last 10 years. DDSs can improve the physicochemical properties of anti-tuberculosis drugs, improving solubility, stability, and bioavailability, with better control of drug release and can target alveolar macrophages. However, more pre-clinical studies and robust bio-relevant analyses are needed for DDSs to become a feasible option to treat patients and attract investors.

Keywords: Mycobacterium tuberculosis, tuberculosis treatment, drug delivery systems, nanotechnology, controlled drug release, pharmacological activity.

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