Tuberculosis (TB), induced by Mycobacterium tuberculosis (MTB), is a fatal infectious disease that kills millions of lives worldwide. The emergence of drug-resistant and multidrug-resistant cases is regarded as one of the most challenging threats to TB control due to the low cure rate. Therefore, TB and drug-resistant TB epidemics urge us to explore more effective therapies. The increasing knowledge of nanotechnology has extended to some nanomedicines for disease treatment in the clinic, which also provides novel possibilities for nano-based medicines for TB treatment. Zinc oxide nanoparticles (ZnO NPs) have gained increasing attention for anti-bacterial uses based on their strong ability to induce reactive oxidative species (ROS) and release bactericidal Zinc ions (Zn2+), which are expected to act as novel strategies for TB and drug-resistant TB treatment. Some active herbal medicines from plant extracts have been widely reported to show attractive anti-bacterial activity for infectious treatment, including TB. Here, we summarize the synthesis of ZnO NPs using plant extracts (green synthesized ZnO NPs) and further discuss their potentials for anti-TB treatments. This is the first review article discussing the anti–TB activity of ZnO NPs produced using plant extracts, which might contribute to the further applications of green synthesized ZnO NPs for anti-TB and drug-resistant TB treatment.
Keywords: Anti-tuberculosis, drug-resistant, Mycobacterium tuberculosis, plant extract, tuberculosis, metal oxide nanoparticles, ZnO nanoparticles
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