Abstract
Toluene and its derivatives have been well established as versatile scaffolds in organic synthesis over the last few decades. This review provides a brief and concise overview of the current status and latest methodologies in the synthetic utility of toluene and its derivatives by exploiting both the alkyl-sp3 and aryl-sp2 carbons via C-H activation. The review also explores the effect of various substituents on the toluene derivatives in facilitating different reactions.
Keywords: Toluene, C-H activation, C-C coupling, C-heteroatom bond formation, cross dehydrogenative coupling, directing groups.
Current Organic Chemistry
Title:Advancements in the Functionalization of Aryl C-sp2 and Alkyl C-sp3 of Toluene Derivatives via C-H Activation
Volume: 25 Issue: 15
Author(s): Kevin George and Sathananthan Kannadasan *
Affiliation:
- Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, Tamil Nadu,India
Keywords: Toluene, C-H activation, C-C coupling, C-heteroatom bond formation, cross dehydrogenative coupling, directing groups.
Abstract: Toluene and its derivatives have been well established as versatile scaffolds in organic synthesis over the last few decades. This review provides a brief and concise overview of the current status and latest methodologies in the synthetic utility of toluene and its derivatives by exploiting both the alkyl-sp3 and aryl-sp2 carbons via C-H activation. The review also explores the effect of various substituents on the toluene derivatives in facilitating different reactions.
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Cite this article as:
George Kevin and Kannadasan Sathananthan *, Advancements in the Functionalization of Aryl C-sp2 and Alkyl C-sp3 of Toluene Derivatives via C-H Activation, Current Organic Chemistry 2021; 25 (15) . https://dx.doi.org/10.2174/1385272825666210608114300
DOI https://dx.doi.org/10.2174/1385272825666210608114300 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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