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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Small Molecule Regulators Targeting NAD+ Biosynthetic Enzymes

Author(s): Alyson Curry, Dawanna White and Yana Cen*

Volume 29, Issue 10, 2022

Published on: 25 August, 2021

Page: [1718 - 1738] Pages: 21

DOI: 10.2174/0929867328666210531144629

Price: $65

Abstract

Nicotinamide adenine dinucleotide (NAD+) is a key player in many metabolic pathways as an activated carrier of electrons. In addition to being the cofactor for redox reactions, NAD+ also serves as the substrate for various enzymatic transformations such as adenylation and ADP-ribosylation. Maintaining cellular NAD+ homeostasis has been suggested as an effective anti-aging strategy. Given the importance of NAD+ in regulating a broad spectrum of cellular events, small molecules targeting NAD+ metabolism have been pursued as therapeutic interventions for the treatment of mitochondrial disorders and agerelated diseases. In this article, small molecule regulators of NAD+ biosynthetic enzymes will be reviewed. The focus will be given to the discovery and development of these molecules, the mechanism of action as well as their therapeutic potentials.

Keywords: Nicotinamide adenine dinucleotide (NAD +), metabolic pathways, electrons, redox reactions, enzymatic transformations, therapeutic potentials.

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