Review Article

Therapeutic Potential, Synthesis, Patent Evaluation and SAR Studies of Thieno[3,2-d]pyrimidine Derivatives: Recent Updates

Author(s): Farhana Islam* and Tasdique M. Quadery

Volume 22, Issue 17, 2021

Published on: 25 May, 2021

Page: [1944 - 1963] Pages: 20

DOI: 10.2174/1389450122666210526094047

Price: $65

Abstract

Thieno[3,2-d]pyrimidine ring framework comprises a significant class of heterocyclics that serve as a promising platform showing different pharmacological activities. The interest in thieno[3,2-d]pyrimidine cores for pharmaceutical products makes this scaffold an exceptionally helpful building block for organic chemistry. This review presents current research on thieno[3,2- d]pyrimidines and elucidates their biological importance in anti-cancer, anti-infectious, anticonvulsant, anti-diabetic, CNS, and osteoporosis drug discoveries. Patents on the thieno[3,2- d]pyrimidines are also elaborated as a piece of useful information. Here, we additionally focus on the synthesis of this vital ring and the discovery of new thieno[3,2-d]pyrimidines.

Keywords: Biological activities, drug molecules, heterocyclic compounds, patents, structure-activity relationship (SAR), thieno[3, 2-d]pyrimidines.

Graphical Abstract

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