Asymmetric organic synthesis is of paramount importance in the development of
drugs. Asymmetric addition reactions such as aldol reaction, Michael addition, and Mannich
addition reactions are important carbon-carbon bond-forming reactions and have been employed
in the synthesis of a broad range of biologically important molecules. Many of these
reactions have been developed under solvent-free conditions or in greener solvents like water.
Several reactions have been developed at room temperature or by using a non-conventional
energy source such as microwave irradiation. Several greener catalysts have been developed
for such reactions. The present review article discusses the application of green chemistry
parameters in the development of selected asymmetric addition reactions leading to biologically
important molecules during the last ten years. Asymmetric aldol reactions, asymmetric
Michael reactions, and different asymmetric addition reactions involving imines such as
Mannich reaction, aza-benzoin reaction, etc. in aqueous media or under solvent-free conditions
have been reviewed. Application of different types of catalysts such as prolinamides, 1,2-diamines, polymer and
magnetic nanoparticle-supported chiral catalysts is demonstrated.
Keywords: Green synthesis, asymmetric additions, enantioselective synthesis, chiral induction, organocatalysis, aldol addition, michael addition,
mannich reaction, henry reaction, drug development.
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