Background: Heavy metals and metalloids like arsenic, cadmium, mercury acts as denaturing
agent for biomolecules. They interfere with protein’s physiological activity by forming a
complex with the protein’s side chain or removing the essential metal ions from metalloproteins
and replacing them. Protein aggregation is an extensive phenomenon in a cell and is linked with
various pathological conditions.
Aim: In this study, we aim to prove that proteins are highly susceptible to arsenite toxicity by
arsenite-induced protein aggregation; and that naringin reduces the aggregation effect.
Methods: Several biophysical techniques were employed to study the protein aggregation due to
arsenite and its prevention by naringin.
Results: Through our experiments, the results showed that aggregation induced by arsenite was reduced
in the presence of naringin at twice the concentration of arsenite.
Conclusion: In conclusion, our study showed that naringin plays a protective role during HSA aggregation
due to arsenite.