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Review Article

New Trends in Biological Activities and Clinical Studies of Quinolinic Analogues: A Review

Author(s): Sandra Elizabeth Barbosa da Silva, José Arion da Silva Moura , Tiago Rafael de Sousa Nunes , Ivan da Rocha Pitta and Marina Galdino da Rocha Pitta*

Volume 23, Issue 5, 2022

Published on: 28 March, 2022

Page: [441 - 457] Pages: 17

DOI: 10.2174/1389450122666210415100151

Price: $65

Abstract

The quinolinic ring, present in several molecules, possesses a great diversity of biological activities. Therefore, this ring is in the structural composition of several candidates of drugs in preclinical and clinical studies; thus, it is necessary to compile these results to facilitate the design of new drugs. For this reason, some of the activities of compounds are selected to examine in this review, such as antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic, and antiviral activities. All publications of scientific articles chosen are dated between 2000 and 2020. In addition to presenting the structures of some natural and synthetic compounds with their activities, we have listed the clinical studies of phases III and IV on antimalarial drugs containing the quinoline nucleus and phase III clinical studies on hydroxychloroquine and chloroquine to assess their possible role in COVID-19. Finally, we have reviewed some of the mechanisms of action, as well as the side effects of some of the quinolinic derivatives.

Keywords: Clinical trials, quinolinic ring, antimalarials, COVID-19, pharmacology, chloroquine.

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Graphical Abstract

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