Abstract
Nanomedicine is an arising field that exploits nanotechnology concepts for pioneered therapy and diagnostics. Colorimetric sensors for tumor markers have displayed interesting benefits compared to conventional systems in clinical laboratory diagnosis. Colorimetric immunoassay-based approaches show up-and-coming results since the goal cancer marker is determined with high sensitivity but without the utilization of advanced/- expensive techniques through an effortless optical color change. Also, colorimetric biosensor has the potential to detect proteins in biological fluids swiftly with high sensitivity, and they are anticipated to play a progressively serious role in tumor diagnosis. We reviewed (covering the period 2015-2020) various studies based on colorimetric sensing strategy using nanostructured materials (highly efficient enzyme mimics, artificial enzymes or nanozymes) to detect different tumor antigens in biological fluids. Specifically, we highlighted the recent progress and efforts in the construction of colorimetric immunosensors. Colorimetric immunosensors can be roughly divided into two main categories: transition metal nanozyme-based sensing and noble metal nanozyme-based sensing.
Keywords: Tumor marker, enzyme-mimics, artificial enzyme, nanozymes, nanoparticles, colorimetry, nanomedicine, clinical analysis.
Current Medicinal Chemistry
Title:A Review on Colorimetric Sensing of Tumor Markers Based on Enzyme-Mimicking Nanomaterials
Volume: 28 Issue: 30
Author(s): Hayati Filik*, Asiye Aslıhan Avan and Zehra Füsun Tokatlı
Affiliation:
- Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, 34320 Avcılar, Istanbul,Turkey
Keywords: Tumor marker, enzyme-mimics, artificial enzyme, nanozymes, nanoparticles, colorimetry, nanomedicine, clinical analysis.
Abstract: Nanomedicine is an arising field that exploits nanotechnology concepts for pioneered therapy and diagnostics. Colorimetric sensors for tumor markers have displayed interesting benefits compared to conventional systems in clinical laboratory diagnosis. Colorimetric immunoassay-based approaches show up-and-coming results since the goal cancer marker is determined with high sensitivity but without the utilization of advanced/- expensive techniques through an effortless optical color change. Also, colorimetric biosensor has the potential to detect proteins in biological fluids swiftly with high sensitivity, and they are anticipated to play a progressively serious role in tumor diagnosis. We reviewed (covering the period 2015-2020) various studies based on colorimetric sensing strategy using nanostructured materials (highly efficient enzyme mimics, artificial enzymes or nanozymes) to detect different tumor antigens in biological fluids. Specifically, we highlighted the recent progress and efforts in the construction of colorimetric immunosensors. Colorimetric immunosensors can be roughly divided into two main categories: transition metal nanozyme-based sensing and noble metal nanozyme-based sensing.
Export Options
About this article
Cite this article as:
Filik Hayati *, Avan Aslıhan Asiye and Tokatlı Füsun Zehra , A Review on Colorimetric Sensing of Tumor Markers Based on Enzyme-Mimicking Nanomaterials, Current Medicinal Chemistry 2021; 28 (30) . https://dx.doi.org/10.2174/0929867328666210412122604
DOI https://dx.doi.org/10.2174/0929867328666210412122604 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
Current advances in inherited cardiomyopathy
Describe in detail all novel advances in multimodality imaging related to inherited cardiomyopathy diagnosis and prognosis. Shed light to deeper phenotypic characterization. Acknowledge recent advances in genetics, genomics and precision medicineread more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Improving Functional Modules Discovery by Enriching Interaction Networks with Gene Profiles
Current Bioinformatics Synthesis and Evaluation of A New Series of Thiazole Derivatives as Potential Antitumor Agents and MMP Inhibitors
Anti-Cancer Agents in Medicinal Chemistry Risk Communication of Vaccines: Challenges in the Post-Trust Environment
Current Drug Safety Mood-Stabilizers Target the Brain Arachidonic Acid Cascade
Current Molecular Pharmacology Green Solvent: Green Shadow on Chemical Synthesis
Current Organic Synthesis Computational Design, Organic Synthesis, and Biological Evaluation of Polyphenol Proteasome Inhibitors: Significance in Drug Discovery and Cancer Prevention
Drug Design Reviews - Online (Discontinued) Nasal <i>In-situ</i> Gel: An Approach to Enhance Therapeutic Benefits of the Drug
Drug Delivery Letters Thioredoxin from Escherichia coli as a Role Model of Molecular Recognition, Folding, Dynamics and Function
Protein & Peptide Letters Induction of Apoptosis by Pierisin-6 in HPV Positive HeLa and HepG2 Cancer Cells is Mediated by the Caspase-3 Dependent Mitochondrial Pathway
Anti-Cancer Agents in Medicinal Chemistry Application of NMR to the Study of Cells and Body Fluids
Current Organic Chemistry Quantitative Determination and Validation of Ivabradine-HCl in Pharmaceutical Formulation and Rabbit Plasma by High Performan ce Liquid Chromatography Method
Current Pharmaceutical Analysis One Hundred Faces of Cyclopamine
Current Pharmaceutical Design Nanotools for the Delivery of Antimicrobial Peptides
Current Drug Targets Strategies for Improving the Quantitative Bioanalytical Performance of LC-MS in Pharmacokinetic Studies
Current Drug Metabolism Mechanism of Action of Flavonoids in Prevention of Inflammation- Associated Skin Cancer
Current Medicinal Chemistry Mushroom Cultivation, Processing and Value-added Products: A Patent Based Review
Recent Patents on Food, Nutrition & Agriculture Intracellular and Extracellular Zinc Detection by Organic Fluorescent Receptor
Current Organic Chemistry Pesticides as Estrogen Disruptors: QSAR for Selective ERα and ERβ Binding of Pesticides
Combinatorial Chemistry & High Throughput Screening Review of the Third Domain Receptor Binding Fragment of Alphafetoprotein (AFP): Plausible Binding of AFP to Lysophospholipid Receptor Targets
Current Drug Targets Interactions Between Plasma Proteins and Naturally Occurring Polyphenols
Current Drug Metabolism