An overview of dietary supplements on obesity and type 2 diabetes: efficacy and mechanisms

(E-pub Abstract Ahead of Print)

Author(s): Xiaohong Liu, Xin Zeng, Wen Liu, Yanrong Lu, Jingqiu Cheng, Younan Chen*

Journal Name: Current Drug Metabolism

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Obesity is a common nutritional disorder, associated with a variety of chronic diseases, among them, type 2 diabetes (T2DM) has emerged as a serious worldwide health problem. Insulin resistance and β cell dysfunction are the main pathological characteristics of T2DM, and obesity and hyperlipidemia are the critical causal factors. It is commonly accepted that dietary factors are of paramount importance in the management of obesity and T2DM. Particularly, many botanic products and their extracts are endowed with a wide spectrum of biological activities, making them extensively studied as anti-obesity and anti-diabetes dietary supplements or new drug candidates. In this review, we aimed to summarize the effects, related mechanisms, and safety issues of dietary continents on obesity and T2DM, to provide theoretical support for better research and development of dietary therapy strategy.

Keywords: Obesity, Type 2 diabetes, Dietary supplements, Plant bioactive ingredients, Natural products, β cell function

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Article Details

(E-pub Abstract Ahead of Print)
DOI: 10.2174/1389200222666210406110450
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