Ionic Liquids in Analytical Chemistry: Applications and Recent Trends

Author(s): Giuseppe Maria Merone, Angela Tartaglia, Enrica Rosato, Cristian D’Ovidio, Abuzar Kabir, Halil Ibrahim Ulusoy, Fabio Savini, Marcello Locatelli*

Journal Name: Current Analytical Chemistry

Volume 17 , Issue 9 , 2021

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Background: Ionic liquids (ILs) are a unique class of compounds consisting exclusively of cations and anions that possess distinctive properties such as low volatility, high thermal stability, miscibility with water and organic solvents, electrolytic conductivity and non-flammability. Ionic liquids have been defined as "design solvents", because it is possible to modify their physical and chemical properties by appropriately choosing cations and anions, in order to meet the specific characteristics based on their potential application.

Introduction: Due of their tunable nature and properties, ILs are considered as the perfect candidates for numerous applications in analytical chemistry including sample preparation, stationary phases in liquid or gas chromatography, additives in capillary electrophoresis, or in mass spectrometry for spectral and electrochemical analysis. In the last years, the number of publications regarding ILs has rapidly increased, highlighting the broad applications of these compounds in various fields of analytical chemistry.

Results: This review first described the main physico-chemical characteristics of ionic liquids, and subsequently reported the various applications in different subdisciplines of analytical chemistry, including the extraction procedure and separation techniques. Furthermore, in each paragraph the most recent applications of ionic liquids in the food, environmental, biological, etc. fields have been described.

Conclusion: Overall, the topic discussed highlights the key role of ionic liquids in analytical chemistry, giving hints for their future applications in chemistry but also in biology and medicine.

Keywords: Ionic liquids, analytical chemistry, sample preparation, extraction techniques, LC, GC.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2021
Published on: 31 March, 2021
Page: [1340 - 1355]
Pages: 16
DOI: 10.2174/1573411017666210331113712
Price: $65

Article Metrics

PDF: 233