Synaptotagmin-1: A Multi-Functional Protein that Mediates Vesicle Docking, Priming, and Fusion

Title:Synaptotagmin-1: A Multi-Functional Protein that Mediates Vesicle Docking, Priming, and Fusion

Volume: 22 Issue: 6

Author(s): Najeeb Ullah*, Ezzouhra El Maaiden, Md. Sahab Uddin*Ghulam Md. Ashraf

Affiliation:

• Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an,China

• Department of Pharmacy, Southeast University, Dhaka,Bangladesh

Keywords: Synaptotagmin-1, vesicle docking, priming, fusion, exocytosis, secretory vesicles.

Abstract: The fusion of secretory vesicles with the plasma membrane depends on the assembly of v-SNAREs (VAMP2/synaptobrevin2) and t-SNAREs (SNAP25/syntaxin1) into the SNARE complex. Vesicles go through several upstream steps, referred to as docking and priming, to gain fusion competence. The vesicular protein synaptotagmin-1 (Syt-1) is the principal Ca²⁺ sensor for fusion in several central nervous system neurons and neuroendocrine cells and part of the docking complex for secretory granules. Syt-1 binds to the acceptor complex such as synaxin1, SNAP-25 on the plasma membrane to facilitate secretory vesicle docking, and upon Ca²⁺-influx, it promotes vesicle fusion. This review assesses the role of the Syt-1 protein involved in the secretory vesicle docking, priming, and fusion.

Cite this article as:

Ullah Najeeb *, Maaiden El Ezzouhra , Uddin Sahab Md. *, Ashraf Md. Ghulam , Synaptotagmin-1: A Multi-Functional Protein that Mediates Vesicle Docking, Priming, and Fusion, Current Protein & Peptide Science 2021; 22 (6) . https://dx.doi.org/10.2174/1389203722666210325110231