Login Register Cart 0
Generic placeholder image

Current Hypertension Reviews

Editor-in-Chief

ISSN (Print): 1573-4021
ISSN (Online): 1875-6506

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

The Impact of Uncontrolled Hypertension on the Longitudinal Systolic Function of the Left Ventricle

Author(s): Nabila Soufi Taleb Bendiab*, Salim Benkhedda, Latifa Henaoui and Abderrahim Meziane Tani

Volume 18, Issue 1, 2022

Published on: 18 February, 2021

Page: [70 - 77] Pages: 8

DOI: 10.2174/1573402117666210218105338

Price: $65

Abstract

Background: The assessment of the longitudinal component of left ventricular (LV) function is of major clinical importance for the early detection of LV contractile impairment. The aim of this study was to determine the impact of uncontrolled hypertension, on LV longitudinal systolic performance.

Methods: The study population included 400 hypertensive patients: 271 patients with uncontrolled blood pressure (BP) and 112 without controlled BP, all patients underwent a complete ultrasound evaluation with the calculation of the LV mass, evaluation of diastolic function as well as longitudinal systolic function.

Results: Conventional echo demonstrated that uncontrolled patients had increased LV mass (P 0.007), LA (left auricular) dimension (P 0.004), left ventricular wall thickness and impairment of diastolic function (E/E’6 ± 2.1 vs 7.4 ±3.0 P=0.001) while no affection of systolic function could be detected. By deformation imaging, there was a reduction in longitudinal strain (apical 4 view -16.2 ±2.9 vs -18.2± 2.6 P 0.02, apical 3 view -17.3 ± 3.3 vs. -18.9 ± 4.1 P 0.01). Similarly, systolic strain rate (SRsys) and early diastolic SR (SRe) reduced significantly in longitudinal direction.

Conclusion: Although EF was not different between uncontrolled patients and controls, LV longitudinal strain and strain rate by 2D speckle tracking were lower in the uncontrolled group.

Keywords: Uncontrolled hypertension, echocardiography, strain, systolic, ventricle, LV mass.

« Previous Next »
Graphical Abstract

[1]
Levy D, Larson MG, Vasan RS, Kannel WB, Ho KK. The progression from hypertension to congestive heart failure. JAMA 1996; 275(20): 1557-62.
[http://dx.doi.org/10.1001/jama.1996.03530440037034] [PMID: 8622246]
[2]
Rovner A, de las Fuentes L, Waggoner AD, Memon N, Chohan R, Dávila-Román VG. Characterization of left ventricular diastolic function in hypertension by use of Doppler tissue imaging and color M-mode techniques. J Am Soc Echocardiogr 2006; 19(7): 872-9.
[http://dx.doi.org/10.1016/j.echo.2006.01.023] [PMID: 16824996]
[3]
Zhou D, Wang S, Tian T. Uncontrolled Hypertension and Risk of Cardiovascular Mortality in China. JAMA Intern Med 2016; 176(8): 1233-4.
[http://dx.doi.org/10.1001/jamainternmed.2016.3819] [PMID: 27479676]
[4]
Iyer AS, Ahmed MI, Filippatos GS, et al. Uncontrolled hypertension and increased risk for incident heart failure in older adults with hypertension: findings from a propensity-matched prospective population study. J Am Soc Hypertens 2010; 4(1): 22-31.
[http://dx.doi.org/10.1016/j.jash.2010.02.002] [PMID: 20374948]
[5]
Huang J, Yan Z-N, Rui Y-F, Fan L, Shen D, Chen D-L. Left Ventricular Systolic Function Changes in Primary Hypertension; Patients Detected by the Strain of Different Myocardium Layers.Wall P, ed Medicine. 2016; 95: p. e2440.
[6]
Leitman M, Lysyansky P, Sidenko S, et al. Two-dimensional strain-a novel software for real-time quantitative echocardiographic assessment of myocardial function. J Am Soc Echocardiogr 2004; 17(10): 1021-9.
[http://dx.doi.org/10.1016/j.echo.2004.06.019] [PMID: 15452466]
[7]
Negishi K, Negishi T, Kurosawa K, et al. Practical guidance in echocardiographic assessment of global longitudinal strain. JACC Cardiovasc Imaging 2015; 8(4): 489-92.
[http://dx.doi.org/10.1016/j.jcmg.2014.06.013] [PMID: 25129519]
[8]
Parati G. European Society of Hypertension guidelines for blood pressure monitoring at home: a summary report of the Second International Consensus Conference on Home Blood Pressure Monitoring. Journal of Hypertension.
[9]
Chobanian AV, Bakris GL, Black HR, et al. National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003; 289(19): 2560-72.
[http://dx.doi.org/10.1001/jama.289.19.2560] [PMID: 12748199]
[10]
Lang RM, Bierig M, Devereux RB, et al. Chamber Quantification Writing Group; American Society of Echocardiography’s Guidelines and Standards Committee; European Association of Echocardiography. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005; 18(12): 1440-63.
[http://dx.doi.org/10.1016/j.echo.2005.10.005] [PMID: 16376782]
[11]
Gosse P, Jullien V, Jarnier P, Lemetayer P, Clementy J. Echocardiographic definition of left ventricular hypertrophy in the hypertensive: which method of indexation of left ventricular mass? J Hum Hypertens 1999; 13(8): 505-9.
[http://dx.doi.org/10.1038/sj.jhh.1000885] [PMID: 10455470]
[12]
Nagueh SF, Appleton CP, Gillebert TC, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. Eur J Echocardiogr 2009; 10(2): 165-93.
[http://dx.doi.org/10.1093/ejechocard/jep007] [PMID: 19270053]
[13]
Paulus WJ, Tschöpe C, Sanderson JE, et al. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur Heart J 2007; 28(20): 2539-50.
[http://dx.doi.org/10.1093/eurheartj/ehm037] [PMID: 17428822]
[14]
Voigt JU, Pedrizzetti G, Lysyansky P, et al. Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging. Eur Heart J Cardiovasc Imaging 2015; 16(1): 1-11.
[http://dx.doi.org/10.1093/ehjci/jeu184] [PMID: 25525063]
[15]
Negishi T, Negishi K, Thavendiranathan P, et al. SUCCOUR Investigators. Effect of experience and training on the concordance and precision of strain measurements. JACC Cardiovasc Imaging 2017; 10(5): 518-22.
[http://dx.doi.org/10.1016/j.jcmg.2016.06.012] [PMID: 27743951]
[16]
Taleb Bendiab N. Meziane-Tani A, Ouabdesselam S, Methia N, Latreche S, Henaoui L, Monsuez J and Benkhedda S. Factors associated with global longitudinal strain decline in hypertensive patients with normal left ventricular ejection fraction. Eur J Prev Cardiol 2017; 24: 1463-72.
[http://dx.doi.org/10.1177/2047487317721644]
[17]
Temmar M, Labat C, Benkhedda S, et al. Prevalence and determinants of hypertension in the Algerian Sahara. J Hypertens 2007; 25(11): 2218-26.
[http://dx.doi.org/10.1097/HJH.0b013e3282dc7549] [PMID: 17921815]
[18]
Edelmiro M, Elías D, Francisco F, Miguel A, Elena B, et al. Prevalence, Diagnosis, Treatment, and Control of Hypertension in Spain. Results of the Di@bet.es Study. 2016.
[19]
Chahoud J. Prévalence of diabetes mellitus among patients with essential arterial hypertension. hypertension Med Liban 2015; 632: 74-80.
[20]
Cryer MJ, Horani T, DiPette DJ. Diabetes and Hypertension: A Comparative Review of Current Guidelines. J Clin Hypertens (Greenwich) 2016; 18(2): 95-100.
[http://dx.doi.org/10.1111/jch.12638] [PMID: 26234374]
[21]
Jung JY, Park SK, Oh C-M, et al. The influence of prehypertension, controlled and uncontrolled hypertension on left ventricular diastolic function and structure in the general Korean population. Hypertens Res 2017; 40(6): 606-12.
[http://dx.doi.org/10.1038/hr.2016.191] [PMID: 28123182]
[22]
Cuspidi C, Facchetti R, Bombelli M, et al. High normal blood pressure and left ventricular hypertrophy echocardiographic findings from the PAMELA population. Hypertension 2019; 73(3): 612-9.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12114]
[23]
Mancia G, Zanchetti A, Agabiti-Rosei E, et al. SAMPLE Study Group. Study on Ambulatory Monitoring of Blood Pressure and Lisinopril Evaluation. Ambulatory blood pressure is superior to clinic blood pressure in predicting treatment-induced regression of left ventricular hypertrophy. Circulation 1997; 95(6): 1464-70.
[http://dx.doi.org/10.1161/01.CIR.95.6.1464] [PMID: 9118514]
[24]
Bliziotis IA, Destounis A, Stergiou GS. Home versus ambulatory and office blood pressure in predicting target organ damage in hypertension: a systematic review and meta-analysis. J Hypertens 2012; 30(7): 1289-99.
[http://dx.doi.org/10.1097/HJH.0b013e3283531eaf] [PMID: 22499289]
[25]
Tavil Y, Kaya MG, Sen N, et al. Assessment of left ventricular systolic and diastolic function by tissue Doppler analysis in patients with hypertension with or without hyperuricemia. Blood Press Monit 2008; 13(2): 79-84.
[http://dx.doi.org/10.1097/MBP.0b013e3282faa732] [PMID: 18347441]
[26]
Zoppini G, Bergamini C, Bonapace S, et al. Association between subclinical left ventricular systolic dysfunction and glycemic control in asymptomatic type 2 diabetic patients with preserved left ventricular function. J Diabetes Complications 2017; 31(6): 1035-40.
[http://dx.doi.org/10.1016/j.jdiacomp.2017.01.021] [PMID: 28258906]
[27]
Shemirani H, Hemmati R, Khosravi A, Gharipour M, Jozan M. Echocardiographic assessment of inappropriate left ventricular mass and left ventricular hypertrophy in patients with diastolic dysfunction. J Res Med Sci 2012; 17(2): 133-7.
[PMID: 23264785]
[28]
Sun JP, Xu TY, Lee AP, et al. Early diastolic dyssynchrony in relation to left ventricular remodeling and function in hypertension. Int J Cardiol 2015; 179: 195-200.
[http://dx.doi.org/10.1016/j.ijcard.2014.10.158] [PMID: 25464444]
[29]
Kane GC, Karon BL, Mahoney DW, et al. Progression of left ventricular diastolic dysfunction and risk of heart failure. JAMA 2011; 306(8): 856-63.
[http://dx.doi.org/10.1001/jama.2011.1201] [PMID: 21862747]
[30]
SoufiTaleb Bendiab N, Meziane-Tani A. Correlation between diastolic function and left ventricular global longitudinal strain decline in hypertensive patients. Archives of Cardiovascular Diseases supplements 2019.
[31]
Russo C, Jin Z, Homma S, et al. Left atrial minimum volume and reservoir function as correlates of left ventricular diastolic function: impact of left ventricular systolic function. Heart 2012; 98(10): 813-20.
[http://dx.doi.org/10.1136/heartjnl-2011-301388] [PMID: 22543839]
[32]
Abhayaratna WP, Seward JB, Appleton CP, et al. Left atrial size: physiologic determinants and clinical applications. J Am Coll Cardiol 2006; 47(12): 2357-63.
[http://dx.doi.org/10.1016/j.jacc.2006.02.048] [PMID: 16781359]
[33]
Sengupta SP, Caracciolo G, Thompson C, Abe H, Sengupta PP. Early impairment of left ventricular function in patients with systemic hypertension: new insights with 2-dimensional speckle tracking echocardiography. Indian Heart J 2013; 65(1): 48-52.
[http://dx.doi.org/10.1016/j.ihj.2012.12.009] [PMID: 23438612]
[34]
Gonçalves S, Cortez-Dias N, Nunes A, et al. Left ventricular systolic dysfunction detected by speckle tracking in hypertensive patients with preserved ejection fraction. Rev Port Cardiol 2014; 33(1): 27-37.
[http://dx.doi.org/10.1016/j.repce.2013.07.013] [PMID: 24405559]
[35]
Kosmala W, Plaksej R, Strotmann JM, et al. Progression of left ventricular functional abnormalities in hypertensive patients with heart failure: an ultrasonic two-dimensional speckle tracking study. J Am Soc Echocardiogr 2008; 21(12): 1309-17.
[http://dx.doi.org/10.1016/j.echo.2008.10.006] [PMID: 19041574]
[36]
Imbalzano E, Zito C, Carerj S, et al. Left ventricular function in hypertension: new insight by speckle tracking echocardiography. Echocardiography 2011; 28(6): 649-57.
[http://dx.doi.org/10.1111/j.1540-8175.2011.01410.x] [PMID: 21676016]
[37]
Ayoub AM, Keddeas VW, Ali YA, El Okl RA. Subclinical LV Dysfunction Detection Using Speckle Tracking Echocardiography in Hypertensive Patients with Preserved LV Ejection Fraction. Clin Med Insights Cardiol 2016; 10: 85-90.
[http://dx.doi.org/10.4137/CMC.S38407] [PMID: 27385916]
[38]
Chen XJ, Sun XL, Zhang Q, et al. Uncontrolled blood pressure as an independent risk factor of early impaired left ventricular systolic function in treated hypertension. Echocardiography 2016; 33(10): 1488-94.
[http://dx.doi.org/10.1111/echo.13289] [PMID: 27385662]
[39]
Tadic M, Cuspidi C, Vukomanovic V, et al. Does masked hypertension impact left ventricular deformation? J Am Soc Hypertens 2016; 10(9): 694-701.
[http://dx.doi.org/10.1016/j.jash.2016.06.032] [PMID: 27461398]
[40]
Rehab I, Mahmoud Kamel A. WaleedAbdou H. Assesment of abnormal LV myocardial deformation properties in obeses patients by 2d based strain and strain rate iaging. Egypt Heart J 2015; 67: 183-91.
[http://dx.doi.org/10.1016/j.ehj.2014.04.005]
[41]
Tsioufis C, Georgiopoulos G, Oikonomou D, et al. Hypertension and Heart Failure with Preserved Ejection Fraction: Connecting the Dots. Curr Vasc Pharmacol 2017; 16(1): 15-22.
[http://dx.doi.org/10.2174/1570161115666170414120532] [PMID: 28413968]

Rights & Permissions Print Cite
Article Metrics
32
1
© 2024 Bentham Science Publishers | Privacy Policy