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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

Direct Synthesis of Aromatic Imine Schiff Bases from β-Phenol Hydroxy Ketone

Author(s): Chang Liu, Haomin Wu, Feng Feng, Wenyuan Liu* and Xueyang Jiang *

Volume 19, Issue 3, 2022

Published on: 17 February, 2021

Page: [181 - 189] Pages: 9

DOI: 10.2174/1570178618666210217121945

Price: $65

Abstract

A facile methodology has been developed to build carbon nitrogen double bond from ketones promoted by the hydroxyl groups in β-phenol hydroxy ketone. It is noteworthy that the halogenated β-phenol hydroxy ketone can chemoselectively react with the amine to afford halogenated phenol imine. It is suitable for certain natural products and also suitable for water-based heteroamines. The method possesses low toxicity and is widely applicable. This strategy is usually used to obtain moderate to good yields of aromatic amine Schiff base.

Keywords: Schiff base, low toxicity synthesis, widely applicable, β-phenol hydroxy ketone, amines, organic chemistry.

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