Natural Substances and Semisynthetic Derivatives as Potential Alternative Products Against SARS-CoV-2

Title:Natural Substances and Semisynthetic Derivatives as Potential Alternative Products Against SARS-CoV-2

Volume: 21 Issue: 13

Author(s): Virginia Fuochi*Pio Maria Furneri

Affiliation:

• Universita degli Studi di Catania, Dipartimento di Scienze Biomediche e Biotecnologiche BIOMETEC, Sez. Microbiologia, Torre Biologica, via S. Sofia 89, 95123,Italy

Keywords: coronavirus, SARS-CoV-2, glycopeptides, probiotics, terpenes, resveratrol, polyphenols.

Abstract:

Background and Objective: Today, a new β-coronavirus called SARS-CoV-2 has emerged and it is causing a global pandemic. Inter-human transmission studies have indicated a significant role of aerosols in the transmission of many respiratory viruses. Hence, it is very important to decrease the spread of the virus through disinfectant agents. This review aimed to provide an overview related to possible alternative inhibitory molecules against this virus.

Method: The literature search was performed in the MEDLINE electronic database using the public access known as NCBI-PUBMED. Keywords "coronavirus" and “SARS-CoV-2” and “COVID19” were used. No specific time range was used.

Results: We provide a review related to structure, anti-coronavirus activity and molecular mechanism of natural substances and semisynthetic derivatives such as glycopeptides, lipopeptides, probiotics, surfactants, terpenes and resveratrol. We also include the latest in vitro experiments with anti-SARSCoV- 2 activity. We also provide the theoretical basis for discussing the prospects of such natural molecules as possible alternative anti-Coronavirus products, so as to develop a complete screening for future applications.

Conclusion: In summary, this review suggest to investigate deeper several molecules most of which belong to natural substances to fight COVID19 disease.

Cite this article as:

Fuochi Virginia *, Furneri Maria Pio , Natural Substances and Semisynthetic Derivatives as Potential Alternative Products Against SARS-CoV-2, Mini-Reviews in Medicinal Chemistry 2021; 21 (13) . https://dx.doi.org/10.2174/1389557521666210203154541