Abstract
Cardiovascular Diseases (CVD) remain the leading cause of mortality and morbidity worldwide. To date, significant progress has been made in developing stimuli-responsive nanosystems that can intrinsically interact with pathological microenvironment to achieve site-specific delivery along with on-demand drug release for precise CVD treatment. Herein, this review summarizes recent advances on smart nanosystems in response to a wide range of biological cues, including pH, enzymes, ROS, shear force, ATP, etc., which can boost drug delivery performance or monitor disease progression in a non-invasive manner. The designs, compositions and main outcomes of the single and multi-responsive nanosystems for drug delivery and/or detection purposes are provided and discussed.
Keywords: Biologically responsive, nanosystems, nanoparticle, drug delivery, stimuli-triggered drug release, cardiovascular diseases.
Current Drug Delivery
Title:Biologically Responsive Nanosystems Targeting Cardiovascular Diseases
Volume: 18 Issue: 7
Author(s): Zhiling Song, Kechen Song, Yi Xiao, Hui Guo, Yizhun Zhu*Xiaolin Wang*
Affiliation:
- State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Taipa, Macao,China
- State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Taipa, Macao,China
Keywords: Biologically responsive, nanosystems, nanoparticle, drug delivery, stimuli-triggered drug release, cardiovascular diseases.
Abstract: Cardiovascular Diseases (CVD) remain the leading cause of mortality and morbidity worldwide. To date, significant progress has been made in developing stimuli-responsive nanosystems that can intrinsically interact with pathological microenvironment to achieve site-specific delivery along with on-demand drug release for precise CVD treatment. Herein, this review summarizes recent advances on smart nanosystems in response to a wide range of biological cues, including pH, enzymes, ROS, shear force, ATP, etc., which can boost drug delivery performance or monitor disease progression in a non-invasive manner. The designs, compositions and main outcomes of the single and multi-responsive nanosystems for drug delivery and/or detection purposes are provided and discussed.
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Cite this article as:
Song Zhiling , Song Kechen , Xiao Yi , Guo Hui , Zhu Yizhun *, Wang Xiaolin *, Biologically Responsive Nanosystems Targeting Cardiovascular Diseases, Current Drug Delivery 2021; 18 (7) . https://dx.doi.org/10.2174/1567201818666210127093743
DOI https://dx.doi.org/10.2174/1567201818666210127093743 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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