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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Natural Flavans and (Iso)Flavanones with Anticancer Activity: A Review

Author(s): Arindam Gangopadhyay*

Volume 25, Issue 9, 2021

Published on: 26 January, 2021

Page: [1028 - 1046] Pages: 19

DOI: 10.2174/1385272825666210126095118

Price: $65

Abstract

The present review describes 108 new examples of naturally occurring flavans and flavanones having cytotoxic potential, which have been reported during the period of 2005 to mid-2020. These compounds are found either as aglycones or as glycosides, comprising flavans, flavanones, isoflavanones and miscellaneous flavanones (homo- and bi-flavanones). The main topics addressed in this review are source, structure, and cytotoxic activity in detail and the structure-activity relationship.

Keywords: Natural flavans and flavanones, cytotoxicity, anticancer activity, aglycones, glycosides, structure-activity relationship.

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Graphical Abstract

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