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Mini-Review Article

Role of Genetic Interactions in Lung Diseases Detection Using Computational Approaches: A Review

Author(s): S. Priya* and R. Manavalan

Volume 1, Issue 2, 2021

Published on: 24 January, 2021

Article ID: e030621190646 Pages: 20

DOI: 10.2174/2665997201666210125091915

Abstract

Genome-wide Association Studies (GWAS) give special insight into genetic differences and environmental influences that are part of different human disorders and provide prognostic help to increase the survival of patients. Lung diseases such as lung cancer, asthma, and tuberculosis are detected by analyzing Single Nucleotide Polymorphism (SNP) genetic variations. The key causes of lung-related diseases are genetic factors, environmental and social behaviors.

The epistasis effects act as a blueprint for the researchers to observe the genetic variation associated with lung diseases. The manual examination of the enormous genetic interactions is complicated to detect the lung syndromes for diagnosis of acute respiratory diseases. Due to its importance, several computational approaches have been modeled to infer epistasis effects. This article includes a comprehensive and multifaceted review of all the relevant genetic studies published between 2006 and 2020. In this critical review, various computational approaches are extensively discussed in detecting respondent epistasis effects for various lung diseases such as asthma, tuberculosis, lung cancer, and nicotine drug dependence.

The analysis shows that different computational models identified candidate genes such as CHRNA4, CHRNB2, BDNF, TAS2R16, TAS2R38, BRCA1, BRCA2, RAD21, IL4Ra, IL-13 and IL-1β, have important causes for genetic variants linked to pulmonary disease. These computational approaches' strengths and limitations are described. The issues behind the computational methods while identifying the lung diseases through epistasis effects and the parameters used by various researchers for their evaluation are also presented.

Keywords: Epistasis, GWAS, genes, lungs diseases, genetic interactions, SNPs.

Graphical Abstract

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