Insight View on Synthetic Strategies and Biological Applications of Pyrimidobenzothiazoles

Title:Insight View on Synthetic Strategies and Biological Applications of Pyrimidobenzothiazoles

Volume: 18 Issue: 8

Author(s): Dinesh Kumar Agarwal, Nusrat Sahiba, Ayushi Sethiya, Jay Soni, Pankaj Teli, Shikha Agarwal*Pradeep Kumar Goyal

Affiliation:

• Synthetic Organic Chemistry Laboratory, Department of Chemistry, MLSU, Udaipur, 313001,India

Keywords: 2-aminobenzothiazole, multicomponent reaction, pyrimidobenzothiazole, synthetic approaches, biological profile, substituted aldehydes.

Abstract: Pyrimidobenzothiazoles and its derivatives are important structural scaffolds in the field of synthetic organic chemistry and medicinal chemistry. The review is focused on one pot multicomponent approaches for generating pyrimidobenzothiazoles and its derivatives along with their interesting biological profile over the last ten years. Several eco-benign and cost effective approaches such as nano catalyst, ionic liquid, metal, solid acid, catalyst free, solvent free, etc. for its synthesis have been discussed in this review. Different synthetic strategies of pyrimidobenzothiazole derivatives have been compiled and discussed using 2-aminobenzothiazole, 1,3 diketones, substituted aldehydes, alkynoic acid, bis-methyl thiomethylene malononitrile, Baylis Hillman acetates, etc.

Cite this article as:

Agarwal Kumar Dinesh , Sahiba Nusrat, Sethiya Ayushi , Soni Jay, Teli Pankaj, Agarwal Shikha *, Goyal Kumar Pradeep, Insight View on Synthetic Strategies and Biological Applications of Pyrimidobenzothiazoles, Mini-Reviews in Organic Chemistry 2021; 18 (8) . https://dx.doi.org/10.2174/1570193X18666210122155016