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Current Traditional Medicine

Editor-in-Chief

ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Mini-Review Article

Prospects of Antiviral Drugs Derived from Natural Products: Targeting SARS-CoV Entry and Replication

Author(s): Tsuey Ning Soon, Wei Hsum Yap, Ya Chee Lim, Chiau Ming Long, Bey Hing Goh* and Yin-Quan Tang*

Volume 7, Issue 5, 2021

Published on: 22 January, 2021

Article ID: e220121190624 Pages: 7

DOI: 10.2174/2215083807666210122151039

Price: $65

Abstract

The recent coronavirus disease (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid spread from continent to continent pose a global health emergency. Researchers are making headway to combat the ongoing COVID-19 to prevent further losses. Many natural antiviral compounds have been explored for their potential application in treating viral infections, including those caused by SARS- and MERS-CoV. This review focuses on natural compounds that have been showing promising results against SARS-CoV, SARS-CoV-2 and MERS-CoV, along with their mechanism of action. The entry and replication of CoV are among the major mechanism for the spread of COVID-19. In this context, natural compounds inhibiting the proteins essential for SARS-CoV-2 entry and replication in the nanomolar (nicotianamine) and micromolar (baicalin, baicalein, scutellarein, dihydromyricetin, quercetagetin, myricetin, amentoflavone, herbacetin, isobavachalcone, quercetin 3‐β‐d‐glucoside, helichrysetin, hirsutenone, hirsutanonol, oregonin, rubranol, rubranoside B, rubranoside A, tanshinones, emodin, and griffithsin) concentration could be potential sources of new anti-SARS-CoV-2 drugs.

Keywords: COVID-19, SARS-CoV-2, 2019-nCoV, SARS-CoV, MERS-CoV, natural products, antiviral drugs, traditional Chinese medicine


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