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Current Organic Chemistry

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ISSN (Online): 1875-5348

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Review Article

Recent Advances in Transition Metal-Free Halogenation of C(sp2)-H Bonds

Author(s): Tian Luo, Shanghui Tian, Jie-Ping Wan* and Yunyun Liu*

Volume 25, Issue 10, 2021

Published on: 22 January, 2021

Page: [1180 - 1193] Pages: 14

DOI: 10.2174/1385272825666210122094423

Price: $65

Abstract

C-X (X = halogen) bonds are indispensable functional groups in organic synthesis by mediating a massive number of important organic reactions. While a variety of different catalytic strategies are available for generating C-X bonds, those methods enabling the C-X bond formation under transition metal-free conditions via the C-H bond functionalization are particularly interesting because of the inherent atom economy and environmental friendliness associated with such methods. Herein, the advancements in the transition metal-free halogenation of C(sp2)-H bond are reviewed.

Keywords: C(sp2)-H bond, halogenation, transition metal-free, carbon arene, hereroaryl, non-aromatics.

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